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Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

Glioblastoma (GB) is the most common and aggressive brain malignancy, characterized by heterogeneity and drug resistance. PTEN, a crucial tumor suppressor, exhibits phosphatase-dependent (PI3K-AKT-mTOR pathway)/independent (nucleus stability) activities to maintain the homeostatic regulation of nume...

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Detalles Bibliográficos
Autores principales:	Xia, Qin, Ali, Sakhawat, Liu, Liqun, Li, Yang, Liu, Xuefeng, Zhang, Lingqiang, Dong, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492558/ https://www.ncbi.nlm.nih.gov/pubmed/32984016 http://dx.doi.org/10.3389/fonc.2020.01569

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