Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)

Progressive supranuclear palsy (PSP) is a neurodegenerative disease based on four-repeat tauopathy pathology. Currently, this entity is not fully recognized in the context of pathogenesis or clinical examination. This review evaluates the association between neuroinflammation and microglial activati...

Descripción completa

Detalles Bibliográficos
Autores principales: Alster, Piotr, Madetko, Natalia, Koziorowski, Dariusz, Friedman, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492584/
https://www.ncbi.nlm.nih.gov/pubmed/32982676
http://dx.doi.org/10.3389/fnins.2020.00893
_version_ 1783582397374136320
author Alster, Piotr
Madetko, Natalia
Koziorowski, Dariusz
Friedman, Andrzej
author_facet Alster, Piotr
Madetko, Natalia
Koziorowski, Dariusz
Friedman, Andrzej
author_sort Alster, Piotr
collection PubMed
description Progressive supranuclear palsy (PSP) is a neurodegenerative disease based on four-repeat tauopathy pathology. Currently, this entity is not fully recognized in the context of pathogenesis or clinical examination. This review evaluates the association between neuroinflammation and microglial activation with the induction of pathological cascades that result in tauopathy pathology and the clinical manifestation of PSP. Multidimensional analysis was performed by evaluating genetic, biochemical, and neuroimaging biomarkers to determine whether neurodegeneration as an effect of neuroinflammation or neuroinflammation is a consequence of neurodegeneration in PSP. To the best of our knowledge, this review is the first to investigate PSP in this context.
format Online
Article
Text
id pubmed-7492584
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74925842020-09-25 Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP) Alster, Piotr Madetko, Natalia Koziorowski, Dariusz Friedman, Andrzej Front Neurosci Neuroscience Progressive supranuclear palsy (PSP) is a neurodegenerative disease based on four-repeat tauopathy pathology. Currently, this entity is not fully recognized in the context of pathogenesis or clinical examination. This review evaluates the association between neuroinflammation and microglial activation with the induction of pathological cascades that result in tauopathy pathology and the clinical manifestation of PSP. Multidimensional analysis was performed by evaluating genetic, biochemical, and neuroimaging biomarkers to determine whether neurodegeneration as an effect of neuroinflammation or neuroinflammation is a consequence of neurodegeneration in PSP. To the best of our knowledge, this review is the first to investigate PSP in this context. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7492584/ /pubmed/32982676 http://dx.doi.org/10.3389/fnins.2020.00893 Text en Copyright © 2020 Alster, Madetko, Koziorowski and Friedman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Alster, Piotr
Madetko, Natalia
Koziorowski, Dariusz
Friedman, Andrzej
Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)
title Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)
title_full Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)
title_fullStr Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)
title_full_unstemmed Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)
title_short Microglial Activation and Inflammation as a Factor in the Pathogenesis of Progressive Supranuclear Palsy (PSP)
title_sort microglial activation and inflammation as a factor in the pathogenesis of progressive supranuclear palsy (psp)
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492584/
https://www.ncbi.nlm.nih.gov/pubmed/32982676
http://dx.doi.org/10.3389/fnins.2020.00893
work_keys_str_mv AT alsterpiotr microglialactivationandinflammationasafactorinthepathogenesisofprogressivesupranuclearpalsypsp
AT madetkonatalia microglialactivationandinflammationasafactorinthepathogenesisofprogressivesupranuclearpalsypsp
AT koziorowskidariusz microglialactivationandinflammationasafactorinthepathogenesisofprogressivesupranuclearpalsypsp
AT friedmanandrzej microglialactivationandinflammationasafactorinthepathogenesisofprogressivesupranuclearpalsypsp

Ejemplares similares