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COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic

As the Coronavirus disease 2019 (COVID-19) pandemic spread to the US, so too did descriptions of an associated coagulopathy and thrombotic complications. Hospitals created institutional protocols for inpatient management of COVID-19 coagulopathy and thrombosis in response to this developing data. We...

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Autores principales: Parks, Anna L., Auerbach, Andrew D., Schnipper, Jeffrey L., Anstey, James E., Sterken, David G., Hecht, Todd E.H., Fang, Margaret C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492800/
https://www.ncbi.nlm.nih.gov/pubmed/32977136
http://dx.doi.org/10.1016/j.thromres.2020.09.018
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author Parks, Anna L.
Auerbach, Andrew D.
Schnipper, Jeffrey L.
Anstey, James E.
Sterken, David G.
Hecht, Todd E.H.
Fang, Margaret C.
author_facet Parks, Anna L.
Auerbach, Andrew D.
Schnipper, Jeffrey L.
Anstey, James E.
Sterken, David G.
Hecht, Todd E.H.
Fang, Margaret C.
author_sort Parks, Anna L.
collection PubMed
description As the Coronavirus disease 2019 (COVID-19) pandemic spread to the US, so too did descriptions of an associated coagulopathy and thrombotic complications. Hospitals created institutional protocols for inpatient management of COVID-19 coagulopathy and thrombosis in response to this developing data. We collected and analyzed protocols from 21 US academic medical centers developed between January and May 2020. We found greatest consensus on recommendations for heparin-based pharmacologic venous thromboembolism (VTE) prophylaxis in COVID-19 patients without contraindications. Protocols differed regarding incorporation of D-dimer tests, dosing of VTE prophylaxis, indications for post-discharge pharmacologic VTE prophylaxis, how to evaluate for VTE, and the use of empiric therapeutic anticoagulation. These findings support ongoing efforts to establish international, evidence-based guidelines.
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spelling pubmed-74928002020-09-16 COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic Parks, Anna L. Auerbach, Andrew D. Schnipper, Jeffrey L. Anstey, James E. Sterken, David G. Hecht, Todd E.H. Fang, Margaret C. Thromb Res Letter to the Editors-in-Chief As the Coronavirus disease 2019 (COVID-19) pandemic spread to the US, so too did descriptions of an associated coagulopathy and thrombotic complications. Hospitals created institutional protocols for inpatient management of COVID-19 coagulopathy and thrombosis in response to this developing data. We collected and analyzed protocols from 21 US academic medical centers developed between January and May 2020. We found greatest consensus on recommendations for heparin-based pharmacologic venous thromboembolism (VTE) prophylaxis in COVID-19 patients without contraindications. Protocols differed regarding incorporation of D-dimer tests, dosing of VTE prophylaxis, indications for post-discharge pharmacologic VTE prophylaxis, how to evaluate for VTE, and the use of empiric therapeutic anticoagulation. These findings support ongoing efforts to establish international, evidence-based guidelines. Elsevier Ltd. 2020-12 2020-09-16 /pmc/articles/PMC7492800/ /pubmed/32977136 http://dx.doi.org/10.1016/j.thromres.2020.09.018 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editors-in-Chief
Parks, Anna L.
Auerbach, Andrew D.
Schnipper, Jeffrey L.
Anstey, James E.
Sterken, David G.
Hecht, Todd E.H.
Fang, Margaret C.
COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
title COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
title_full COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
title_fullStr COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
title_full_unstemmed COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
title_short COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
title_sort covid-19 coagulopathy and thrombosis: analysis of hospital protocols in response to the rapidly evolving pandemic
topic Letter to the Editors-in-Chief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492800/
https://www.ncbi.nlm.nih.gov/pubmed/32977136
http://dx.doi.org/10.1016/j.thromres.2020.09.018
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