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Roles of TRP Channels in Neurological Diseases

Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, a...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Tu, Sheng, Zhang, Jianmin, Shao, Anwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492880/
https://www.ncbi.nlm.nih.gov/pubmed/32963700
http://dx.doi.org/10.1155/2020/7289194
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author Wang, Rui
Tu, Sheng
Zhang, Jianmin
Shao, Anwen
author_facet Wang, Rui
Tu, Sheng
Zhang, Jianmin
Shao, Anwen
author_sort Wang, Rui
collection PubMed
description Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the cerebral vascular endothelium and smooth muscle. Members of this channel superfamily show a wide variety of mechanisms ranging from ligand binding to voltage, physical, and chemical stimuli, implying the promising therapeutic potential of TRP in neurological diseases. In this review, we focus on the physiological functions of TRP channels in the brain and the pathological roles in neurological disorders to explore future potential neuroprotective strategies.
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spelling pubmed-74928802020-09-21 Roles of TRP Channels in Neurological Diseases Wang, Rui Tu, Sheng Zhang, Jianmin Shao, Anwen Oxid Med Cell Longev Review Article Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the cerebral vascular endothelium and smooth muscle. Members of this channel superfamily show a wide variety of mechanisms ranging from ligand binding to voltage, physical, and chemical stimuli, implying the promising therapeutic potential of TRP in neurological diseases. In this review, we focus on the physiological functions of TRP channels in the brain and the pathological roles in neurological disorders to explore future potential neuroprotective strategies. Hindawi 2020-09-04 /pmc/articles/PMC7492880/ /pubmed/32963700 http://dx.doi.org/10.1155/2020/7289194 Text en Copyright © 2020 Rui Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Rui
Tu, Sheng
Zhang, Jianmin
Shao, Anwen
Roles of TRP Channels in Neurological Diseases
title Roles of TRP Channels in Neurological Diseases
title_full Roles of TRP Channels in Neurological Diseases
title_fullStr Roles of TRP Channels in Neurological Diseases
title_full_unstemmed Roles of TRP Channels in Neurological Diseases
title_short Roles of TRP Channels in Neurological Diseases
title_sort roles of trp channels in neurological diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492880/
https://www.ncbi.nlm.nih.gov/pubmed/32963700
http://dx.doi.org/10.1155/2020/7289194
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