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Serum Leptin as a Marker for Severity of Endometriosis

BACKGROUND: Endometriosis a disease of theories, and one of the important causes of chronic pelvic pain, dysmenorrhea, dyspareunia, and subfertility. Surgery is the mainstay step for the diagnosis; noninvasive test is the goal in the future. Aim of Study. To test the role of serum leptin in determin...

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Autores principales: Hussein, Shatha Sami, Farhan, Fatin Shallal, Ibrahim Ali, Alaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492927/
https://www.ncbi.nlm.nih.gov/pubmed/32963544
http://dx.doi.org/10.1155/2020/6290693
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author Hussein, Shatha Sami
Farhan, Fatin Shallal
Ibrahim Ali, Alaa
author_facet Hussein, Shatha Sami
Farhan, Fatin Shallal
Ibrahim Ali, Alaa
author_sort Hussein, Shatha Sami
collection PubMed
description BACKGROUND: Endometriosis a disease of theories, and one of the important causes of chronic pelvic pain, dysmenorrhea, dyspareunia, and subfertility. Surgery is the mainstay step for the diagnosis; noninvasive test is the goal in the future. Aim of Study. To test the role of serum leptin in determination of severity of endometriosis. Study Design. A cross-sectional study done in Al-Yarmouk Teaching Hospital from 1st of January 2018 to 1st of January 2019. METHODS: 60 BMI-matched patients were involved in the study. A study group of 30 patients were operated either by laparoscopy or laparotomy for many reasons diagnosed as endometriosis by histopathology, and 30 normal women as a control group underwent elective surgery. Blood sample was taken from all patients in the theater room when laparoscopy finding went with endometriosis, and classifying according to surgical staging of endometriosis, the level of serum leptin was measured by ELISA using Human LEP (Leptin) ELISA Kit. The recording of finding of laparoscopy after conforming of diagnosis by histopathology was compared with the result of serum leptin. RESULT: The result shows no significant difference between the two groups regarding parity and age; however, the level of serum leptin was significantly high in the endometriosis group than in the control group. The P value was less than 0.05. Also, the result shows no significant differences between serum leptin in both groups according to the symptom but there was a significant difference with surgical staging. The mean of the level of serum leptin in stage 1 was 214.8, while it was 340.3 in stage 4. CONCLUSION: Serum leptin can be used as a marker of severity of endometriosis.
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spelling pubmed-74929272020-09-21 Serum Leptin as a Marker for Severity of Endometriosis Hussein, Shatha Sami Farhan, Fatin Shallal Ibrahim Ali, Alaa Obstet Gynecol Int Research Article BACKGROUND: Endometriosis a disease of theories, and one of the important causes of chronic pelvic pain, dysmenorrhea, dyspareunia, and subfertility. Surgery is the mainstay step for the diagnosis; noninvasive test is the goal in the future. Aim of Study. To test the role of serum leptin in determination of severity of endometriosis. Study Design. A cross-sectional study done in Al-Yarmouk Teaching Hospital from 1st of January 2018 to 1st of January 2019. METHODS: 60 BMI-matched patients were involved in the study. A study group of 30 patients were operated either by laparoscopy or laparotomy for many reasons diagnosed as endometriosis by histopathology, and 30 normal women as a control group underwent elective surgery. Blood sample was taken from all patients in the theater room when laparoscopy finding went with endometriosis, and classifying according to surgical staging of endometriosis, the level of serum leptin was measured by ELISA using Human LEP (Leptin) ELISA Kit. The recording of finding of laparoscopy after conforming of diagnosis by histopathology was compared with the result of serum leptin. RESULT: The result shows no significant difference between the two groups regarding parity and age; however, the level of serum leptin was significantly high in the endometriosis group than in the control group. The P value was less than 0.05. Also, the result shows no significant differences between serum leptin in both groups according to the symptom but there was a significant difference with surgical staging. The mean of the level of serum leptin in stage 1 was 214.8, while it was 340.3 in stage 4. CONCLUSION: Serum leptin can be used as a marker of severity of endometriosis. Hindawi 2020-09-07 /pmc/articles/PMC7492927/ /pubmed/32963544 http://dx.doi.org/10.1155/2020/6290693 Text en Copyright © 2020 Shatha Sami Hussein et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hussein, Shatha Sami
Farhan, Fatin Shallal
Ibrahim Ali, Alaa
Serum Leptin as a Marker for Severity of Endometriosis
title Serum Leptin as a Marker for Severity of Endometriosis
title_full Serum Leptin as a Marker for Severity of Endometriosis
title_fullStr Serum Leptin as a Marker for Severity of Endometriosis
title_full_unstemmed Serum Leptin as a Marker for Severity of Endometriosis
title_short Serum Leptin as a Marker for Severity of Endometriosis
title_sort serum leptin as a marker for severity of endometriosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492927/
https://www.ncbi.nlm.nih.gov/pubmed/32963544
http://dx.doi.org/10.1155/2020/6290693
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