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A promising iPS-based single-cell cloning strategy revealing signatures of somatic mutations in heterogeneous normal cells
Single-cell genomics has advanced rapidly as trace-DNA amplification technologies evolved. However, current technologies are subject to a variety of pitfalls such as contamination, uneven genomic coverage, and amplification errors. Even for the “golden” strategy of single stem cell-derived clonal fo...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493045/ https://www.ncbi.nlm.nih.gov/pubmed/32994891 http://dx.doi.org/10.1016/j.csbj.2020.08.026 |