MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?

MicroRNAs (miR) are single-stranded RNA of 21-23 nucleotides in length that repress mRNA translation and induces mRNA degradation. miR acts as an endogenous factor of gene expression and plays a crucial part in cancer biology such as cell development, proliferation, differentiation, and apoptosis. N...

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Autores principales: Wu, Xueliang, Yan, Fuguo, Wang, Likun, Sun, Guangyuan, Liu, Jinyu, Qu, Ming, Wang, Yicheng, Li, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493075/
https://www.ncbi.nlm.nih.gov/pubmed/32984321
http://dx.doi.org/10.3389/fcell.2020.00812
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author Wu, Xueliang
Yan, Fuguo
Wang, Likun
Sun, Guangyuan
Liu, Jinyu
Qu, Ming
Wang, Yicheng
Li, Tian
author_facet Wu, Xueliang
Yan, Fuguo
Wang, Likun
Sun, Guangyuan
Liu, Jinyu
Qu, Ming
Wang, Yicheng
Li, Tian
author_sort Wu, Xueliang
collection PubMed
description MicroRNAs (miR) are single-stranded RNA of 21-23 nucleotides in length that repress mRNA translation and induces mRNA degradation. miR acts as an endogenous factor of gene expression and plays a crucial part in cancer biology such as cell development, proliferation, differentiation, and apoptosis. Numerous research has indicated that dysregulation of miR associates with colorectal carcinogenesis. In this review article, we firstly introduce the background of miR and colorectal cancer, and the mechanisms of miR in colorectal cancer, such as the proliferation, apoptosis, and progression. Then, we summarize the theranostic value of miR in colorectal cancer. Eventually, we discuss the potential directions and perspectives of miR. This article serves as a guide for further studies and implicate miR as a potent theranostic target for colorectal cancer.
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spelling pubmed-74930752020-09-24 MicroRNA: Another Pharmacological Avenue for Colorectal Cancer? Wu, Xueliang Yan, Fuguo Wang, Likun Sun, Guangyuan Liu, Jinyu Qu, Ming Wang, Yicheng Li, Tian Front Cell Dev Biol Cell and Developmental Biology MicroRNAs (miR) are single-stranded RNA of 21-23 nucleotides in length that repress mRNA translation and induces mRNA degradation. miR acts as an endogenous factor of gene expression and plays a crucial part in cancer biology such as cell development, proliferation, differentiation, and apoptosis. Numerous research has indicated that dysregulation of miR associates with colorectal carcinogenesis. In this review article, we firstly introduce the background of miR and colorectal cancer, and the mechanisms of miR in colorectal cancer, such as the proliferation, apoptosis, and progression. Then, we summarize the theranostic value of miR in colorectal cancer. Eventually, we discuss the potential directions and perspectives of miR. This article serves as a guide for further studies and implicate miR as a potent theranostic target for colorectal cancer. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7493075/ /pubmed/32984321 http://dx.doi.org/10.3389/fcell.2020.00812 Text en Copyright © 2020 Wu, Yan, Wang, Sun, Liu, Qu, Wang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wu, Xueliang
Yan, Fuguo
Wang, Likun
Sun, Guangyuan
Liu, Jinyu
Qu, Ming
Wang, Yicheng
Li, Tian
MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
title MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
title_full MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
title_fullStr MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
title_full_unstemmed MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
title_short MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?
title_sort microrna: another pharmacological avenue for colorectal cancer?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493075/
https://www.ncbi.nlm.nih.gov/pubmed/32984321
http://dx.doi.org/10.3389/fcell.2020.00812
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