Cytokine storm and use of anakinra in a patient with COVID-19

We present a case of a 50-year-old man with COVID-19 infection and acute respiratory distress syndrome as a result of a cytokine storm and use of anakinra, an interleukin 1-receptor antagonist that is normally used in the treatment of autoinflammatory disorders in adult patients. We saw a reduction...

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Detalles Bibliográficos
Autores principales: Nemchand, Priyanka, Tahir, Hassan, Mediwake, Rapti, Lee, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493115/
https://www.ncbi.nlm.nih.gov/pubmed/32933914
http://dx.doi.org/10.1136/bcr-2020-237525
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author Nemchand, Priyanka
Tahir, Hassan
Mediwake, Rapti
Lee, Jeffrey
author_facet Nemchand, Priyanka
Tahir, Hassan
Mediwake, Rapti
Lee, Jeffrey
author_sort Nemchand, Priyanka
collection PubMed
description We present a case of a 50-year-old man with COVID-19 infection and acute respiratory distress syndrome as a result of a cytokine storm and use of anakinra, an interleukin 1-receptor antagonist that is normally used in the treatment of autoinflammatory disorders in adult patients. We saw a reduction in oxygen requirement and improvements in inflammatory markers and ferritin. Although we cannot determine its clinical efficacy from one case study, it may have a positive effect on the proinflammatory state that is associated with cytokine storm in COVID-19 infection.
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spelling pubmed-74931152020-09-24 Cytokine storm and use of anakinra in a patient with COVID-19 Nemchand, Priyanka Tahir, Hassan Mediwake, Rapti Lee, Jeffrey BMJ Case Rep Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect We present a case of a 50-year-old man with COVID-19 infection and acute respiratory distress syndrome as a result of a cytokine storm and use of anakinra, an interleukin 1-receptor antagonist that is normally used in the treatment of autoinflammatory disorders in adult patients. We saw a reduction in oxygen requirement and improvements in inflammatory markers and ferritin. Although we cannot determine its clinical efficacy from one case study, it may have a positive effect on the proinflammatory state that is associated with cytokine storm in COVID-19 infection. BMJ Publishing Group 2020-09-15 /pmc/articles/PMC7493115/ /pubmed/32933914 http://dx.doi.org/10.1136/bcr-2020-237525 Text en © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage
spellingShingle Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
Nemchand, Priyanka
Tahir, Hassan
Mediwake, Rapti
Lee, Jeffrey
Cytokine storm and use of anakinra in a patient with COVID-19
title Cytokine storm and use of anakinra in a patient with COVID-19
title_full Cytokine storm and use of anakinra in a patient with COVID-19
title_fullStr Cytokine storm and use of anakinra in a patient with COVID-19
title_full_unstemmed Cytokine storm and use of anakinra in a patient with COVID-19
title_short Cytokine storm and use of anakinra in a patient with COVID-19
title_sort cytokine storm and use of anakinra in a patient with covid-19
topic Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493115/
https://www.ncbi.nlm.nih.gov/pubmed/32933914
http://dx.doi.org/10.1136/bcr-2020-237525
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