Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial

BACKGROUND: Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-syno...

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Detalles Bibliográficos
Autores principales: Zhu, Zhaohua, Yu, Qinghong, Leng, Xiaomei, Han, Weiyu, Li, Zhanguo, Huang, Cibo, Gu, Jieruo, Zhao, Yi, Wang, Kang, Li, Tianwang, Mei, Yifang, Xu, Jianhua, Zhang, Zhiyi, Hunter, David, Cicuttini, Flavia, Zeng, Xiaofeng, Ding, Changhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493135/
https://www.ncbi.nlm.nih.gov/pubmed/32938470
http://dx.doi.org/10.1186/s13063-020-04687-3

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