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Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme

BACKGROUND AND AIMS: Oral systemic pan-Janus kinase [JAK] inhibition is effective for ulcerative colitis [UC] but is limited by toxicities. We describe preclinical to clinical translation of TD-1473—an oral gut-selective pan-JAK inhibitor—from in vitro characterization through a Phase 1b study in pa...

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Detalles Bibliográficos
Autores principales:	Sandborn, William J, Nguyen, Deanna D, Beattie, David T, Brassil, Patrick, Krey, Whitney, Woo, Jacky, Situ, Eva, Sana, Reuben, Sandvik, Erik, Pulido-Rios, M Teresa, Bhandari, Raj, Leighton, Jonathan A, Ganeshappa, Ravi, Boyle, David L, Abhyankar, Brihad, Kleinschek, Melanie A, Graham, Richard A, Panes, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493219/ https://www.ncbi.nlm.nih.gov/pubmed/32161949 http://dx.doi.org/10.1093/ecco-jcc/jjaa049

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