Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

BACKGROUND: Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. METHODS: We established inducible transgene expression in clinically relevant patient-derived xenogra...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wen-Hsin, Mrozek-Gorska, Paulina, Wirth, Anna-Katharina, Herold, Tobias, Schwarzkopf, Larissa, Pich, Dagmar, Völse, Kerstin, Melo-Narváez, M. Camila, Carlet, Michela, Hammerschmidt, Wolfgang, Jeremias, Irmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493381/
https://www.ncbi.nlm.nih.gov/pubmed/32944247
http://dx.doi.org/10.1186/s40364-020-00226-z

Ejemplares similares

Ejemplares similares