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Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI)
Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493815/ https://www.ncbi.nlm.nih.gov/pubmed/33036839 http://dx.doi.org/10.1016/j.tmrv.2020.08.002 |
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author | Zeeuw van der Laan, Eveline A.N. van der Velden, Saskia Porcelijn, Leendert Semple, John W. van der Schoot, C. Ellen Kapur, Rick |
author_facet | Zeeuw van der Laan, Eveline A.N. van der Velden, Saskia Porcelijn, Leendert Semple, John W. van der Schoot, C. Ellen Kapur, Rick |
author_sort | Zeeuw van der Laan, Eveline A.N. |
collection | PubMed |
description | Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well defined; however, it has been hypothesized that recipient platelets and transfused platelets both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that recipient platelets may play a pathogenic role in antibody-mediated TRALI; however, their contribution appears to be limited. It is imperative to first validate the involvement of recipient platelets by standardizing the animal models, methods, reagents, and readouts for lung injury and taking the animal housing environment into consideration. For the involvement of transfused platelets in TRALI, it appears that predominantly lipids such as ceramide in stored platelets are able to induce TRALI in animal models. These studies will also need to be validated, and moreover, the platelet-derived lipid-mediated mechanisms leading to TRALI will need to be investigated. |
format | Online Article Text |
id | pubmed-7493815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74938152020-09-17 Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) Zeeuw van der Laan, Eveline A.N. van der Velden, Saskia Porcelijn, Leendert Semple, John W. van der Schoot, C. Ellen Kapur, Rick Transfus Med Rev Article Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well defined; however, it has been hypothesized that recipient platelets and transfused platelets both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that recipient platelets may play a pathogenic role in antibody-mediated TRALI; however, their contribution appears to be limited. It is imperative to first validate the involvement of recipient platelets by standardizing the animal models, methods, reagents, and readouts for lung injury and taking the animal housing environment into consideration. For the involvement of transfused platelets in TRALI, it appears that predominantly lipids such as ceramide in stored platelets are able to induce TRALI in animal models. These studies will also need to be validated, and moreover, the platelet-derived lipid-mediated mechanisms leading to TRALI will need to be investigated. Elsevier Inc. 2020-10 2020-09-16 /pmc/articles/PMC7493815/ /pubmed/33036839 http://dx.doi.org/10.1016/j.tmrv.2020.08.002 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zeeuw van der Laan, Eveline A.N. van der Velden, Saskia Porcelijn, Leendert Semple, John W. van der Schoot, C. Ellen Kapur, Rick Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) |
title | Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) |
title_full | Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) |
title_fullStr | Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) |
title_full_unstemmed | Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) |
title_short | Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI) |
title_sort | evaluation of platelet responses in transfusion-related acute lung injury (trali) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493815/ https://www.ncbi.nlm.nih.gov/pubmed/33036839 http://dx.doi.org/10.1016/j.tmrv.2020.08.002 |
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