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Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol
BACKGROUND: Stroke is a major cause of disability and stroke incidence increases with age. Stroke frequently results in permanent limitations of mobility, and, consequently, the need for the help of others in activities of daily living. In order to optimize rehabilitative efforts and their functiona...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493846/ https://www.ncbi.nlm.nih.gov/pubmed/32938425 http://dx.doi.org/10.1186/s12883-020-01920-z |
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author | Rössler, R. Bridenbaugh, S. A. Engelter, S. T. Weibel, R. Infanger, D. Giannouli, E. Sofios, A. Iendra, L. Portegijs, E. Rantanen, T. Streese, L. Hanssen, H. Roth, R. Schmidt-Trucksäss, A. Peters, N. Hinrichs, T. |
author_facet | Rössler, R. Bridenbaugh, S. A. Engelter, S. T. Weibel, R. Infanger, D. Giannouli, E. Sofios, A. Iendra, L. Portegijs, E. Rantanen, T. Streese, L. Hanssen, H. Roth, R. Schmidt-Trucksäss, A. Peters, N. Hinrichs, T. |
author_sort | Rössler, R. |
collection | PubMed |
description | BACKGROUND: Stroke is a major cause of disability and stroke incidence increases with age. Stroke frequently results in permanent limitations of mobility, and, consequently, the need for the help of others in activities of daily living. In order to optimize rehabilitative efforts and their functional outcomes, detailed knowledge of the functional recovery process, regarding mobility, is needed. Objectives of the MOBITEC-Stroke study are: 1.) To characterize mobility, including lower extremity physical function (LEPF) and life space (the geospatial extent of all of a person’s movements), and changes in mobility within the first year after stroke. 2.) To identify and characterize subgroups with different mobility trajectories. 3.) To evaluate whether changes in LEPF are associated with changes in life-space. 4.) To evaluate participants’ reasons for going outdoors, transportation use, and assistance needed for outdoor movement. METHODS: Patients with incident first stroke who live in their own homes (target N = 59, based on sample size calculation) will be included in this cohort study. At 3, 6, 9, and 12 months after stroke a battery of mobility tests will be performed at the study centre, including laboratory-based tests of balance and strength, and quantitative gait analysis. Life-space assessment (including 1-week GPS measurements) will be performed in participants’ real life. Semantic information on visited locations (reasons for going outdoors, transportation use, assistance needed) will be collected by using interactive digital maps. Linear mixed effects models will be used to model the trajectories of mobility measures for the total sample and for predefined subgroups. As an exploratory analysis, growth mixture models (GMMs) will be used to identify relevant subgroups with different trajectories. Linear mixed effect models will be used to test whether changes in LEPF parameters are associated with changes in life-space. Participants’ motivation for going outdoors, transportation use, and assistance needed for outdoor mobility will be analysed descriptively. DISCUSSION: A comprehensive and detailed knowledge of recovery patterns will enable the planning of targeted and adaptively tailored rehabilitation measures. Information about patients’ reasons for outdoor mobility will provide the opportunity to define individualized and patient-oriented rehabilitation goals. TRIAL REGISTRATION: ISRCTN85999967 (on 13 August 2020; retrospectively). |
format | Online Article Text |
id | pubmed-7493846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74938462020-09-23 Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol Rössler, R. Bridenbaugh, S. A. Engelter, S. T. Weibel, R. Infanger, D. Giannouli, E. Sofios, A. Iendra, L. Portegijs, E. Rantanen, T. Streese, L. Hanssen, H. Roth, R. Schmidt-Trucksäss, A. Peters, N. Hinrichs, T. BMC Neurol Study Protocol BACKGROUND: Stroke is a major cause of disability and stroke incidence increases with age. Stroke frequently results in permanent limitations of mobility, and, consequently, the need for the help of others in activities of daily living. In order to optimize rehabilitative efforts and their functional outcomes, detailed knowledge of the functional recovery process, regarding mobility, is needed. Objectives of the MOBITEC-Stroke study are: 1.) To characterize mobility, including lower extremity physical function (LEPF) and life space (the geospatial extent of all of a person’s movements), and changes in mobility within the first year after stroke. 2.) To identify and characterize subgroups with different mobility trajectories. 3.) To evaluate whether changes in LEPF are associated with changes in life-space. 4.) To evaluate participants’ reasons for going outdoors, transportation use, and assistance needed for outdoor movement. METHODS: Patients with incident first stroke who live in their own homes (target N = 59, based on sample size calculation) will be included in this cohort study. At 3, 6, 9, and 12 months after stroke a battery of mobility tests will be performed at the study centre, including laboratory-based tests of balance and strength, and quantitative gait analysis. Life-space assessment (including 1-week GPS measurements) will be performed in participants’ real life. Semantic information on visited locations (reasons for going outdoors, transportation use, assistance needed) will be collected by using interactive digital maps. Linear mixed effects models will be used to model the trajectories of mobility measures for the total sample and for predefined subgroups. As an exploratory analysis, growth mixture models (GMMs) will be used to identify relevant subgroups with different trajectories. Linear mixed effect models will be used to test whether changes in LEPF parameters are associated with changes in life-space. Participants’ motivation for going outdoors, transportation use, and assistance needed for outdoor mobility will be analysed descriptively. DISCUSSION: A comprehensive and detailed knowledge of recovery patterns will enable the planning of targeted and adaptively tailored rehabilitation measures. Information about patients’ reasons for outdoor mobility will provide the opportunity to define individualized and patient-oriented rehabilitation goals. TRIAL REGISTRATION: ISRCTN85999967 (on 13 August 2020; retrospectively). BioMed Central 2020-09-16 /pmc/articles/PMC7493846/ /pubmed/32938425 http://dx.doi.org/10.1186/s12883-020-01920-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Rössler, R. Bridenbaugh, S. A. Engelter, S. T. Weibel, R. Infanger, D. Giannouli, E. Sofios, A. Iendra, L. Portegijs, E. Rantanen, T. Streese, L. Hanssen, H. Roth, R. Schmidt-Trucksäss, A. Peters, N. Hinrichs, T. Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol |
title | Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol |
title_full | Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol |
title_fullStr | Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol |
title_full_unstemmed | Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol |
title_short | Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol |
title_sort | recovery of mobility function and life-space mobility after ischemic stroke: the mobitec-stroke study protocol |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493846/ https://www.ncbi.nlm.nih.gov/pubmed/32938425 http://dx.doi.org/10.1186/s12883-020-01920-z |
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