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Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication
BACKGROUND: Multimorbidity is a growing challenge worldwide. In this nationwide study, we investigated the prevalence of multimorbidity and polypharmacy at the time of diagnosis across 20 cancers. METHODS: We conducted a nationwide register-based cohort study of all Danish residents with a first pri...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493878/ https://www.ncbi.nlm.nih.gov/pubmed/32632149 http://dx.doi.org/10.1038/s41416-020-0950-3 |
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author | Loeppenthin, Katrine Dalton, Susanne Oksbjerg Johansen, Christoffer Andersen, Elisabeth Christensen, Mikkel Bring Pappot, Helle Petersen, Lone Nørgaard Thisted, Lise Bjerrum Frølich, Anne Mortensen, Christiane Ehlers Lassen, Ulrik Ørsted, Jytte Bidstrup, Pernille Envold |
author_facet | Loeppenthin, Katrine Dalton, Susanne Oksbjerg Johansen, Christoffer Andersen, Elisabeth Christensen, Mikkel Bring Pappot, Helle Petersen, Lone Nørgaard Thisted, Lise Bjerrum Frølich, Anne Mortensen, Christiane Ehlers Lassen, Ulrik Ørsted, Jytte Bidstrup, Pernille Envold |
author_sort | Loeppenthin, Katrine |
collection | PubMed |
description | BACKGROUND: Multimorbidity is a growing challenge worldwide. In this nationwide study, we investigated the prevalence of multimorbidity and polypharmacy at the time of diagnosis across 20 cancers. METHODS: We conducted a nationwide register-based cohort study of all Danish residents with a first primary cancer diagnosed between 1 January 2005 and 31 December 2015. Multimorbidity was defined as one or more of 20 conditions (131 specific diagnoses) registered in the Danish National Patient Registry < 5 years before the cancer diagnosis. Polypharmacy was defined as five or more medications registered in the Danish National Prescription Registry and redeemed twice 2–12 months before the cancer diagnosis. RESULTS: We included 261,745 patients with a first primary cancer, of whom 55% had at least one comorbid condition at diagnosis and 27% had two or more. The most prevalent conditions at the time of cancer diagnosis were cardiovascular disease, chronic obstructive pulmonary disease, diabetes, stroke and depression/anxiety disorder. Polypharmacy was present in one-third of the cancer patients with antihypertensives, anti-thrombotic agents, anti-hyperlipidaemic agents, analgesics and diuretics as the most prevalent redeemed medications. CONCLUSION: Among patients with a newly established cancer diagnosis, 55% had at least one comorbid condition and 32% were exposed to polypharmacy. |
format | Online Article Text |
id | pubmed-7493878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74938782021-07-07 Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication Loeppenthin, Katrine Dalton, Susanne Oksbjerg Johansen, Christoffer Andersen, Elisabeth Christensen, Mikkel Bring Pappot, Helle Petersen, Lone Nørgaard Thisted, Lise Bjerrum Frølich, Anne Mortensen, Christiane Ehlers Lassen, Ulrik Ørsted, Jytte Bidstrup, Pernille Envold Br J Cancer Article BACKGROUND: Multimorbidity is a growing challenge worldwide. In this nationwide study, we investigated the prevalence of multimorbidity and polypharmacy at the time of diagnosis across 20 cancers. METHODS: We conducted a nationwide register-based cohort study of all Danish residents with a first primary cancer diagnosed between 1 January 2005 and 31 December 2015. Multimorbidity was defined as one or more of 20 conditions (131 specific diagnoses) registered in the Danish National Patient Registry < 5 years before the cancer diagnosis. Polypharmacy was defined as five or more medications registered in the Danish National Prescription Registry and redeemed twice 2–12 months before the cancer diagnosis. RESULTS: We included 261,745 patients with a first primary cancer, of whom 55% had at least one comorbid condition at diagnosis and 27% had two or more. The most prevalent conditions at the time of cancer diagnosis were cardiovascular disease, chronic obstructive pulmonary disease, diabetes, stroke and depression/anxiety disorder. Polypharmacy was present in one-third of the cancer patients with antihypertensives, anti-thrombotic agents, anti-hyperlipidaemic agents, analgesics and diuretics as the most prevalent redeemed medications. CONCLUSION: Among patients with a newly established cancer diagnosis, 55% had at least one comorbid condition and 32% were exposed to polypharmacy. Nature Publishing Group UK 2020-07-07 2020-09-15 /pmc/articles/PMC7493878/ /pubmed/32632149 http://dx.doi.org/10.1038/s41416-020-0950-3 Text en © The Author(s), under exclusive licence to Cancer Research UK 2020 https://creativecommons.org/licenses/by/4.0/Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0). |
spellingShingle | Article Loeppenthin, Katrine Dalton, Susanne Oksbjerg Johansen, Christoffer Andersen, Elisabeth Christensen, Mikkel Bring Pappot, Helle Petersen, Lone Nørgaard Thisted, Lise Bjerrum Frølich, Anne Mortensen, Christiane Ehlers Lassen, Ulrik Ørsted, Jytte Bidstrup, Pernille Envold Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication |
title | Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication |
title_full | Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication |
title_fullStr | Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication |
title_full_unstemmed | Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication |
title_short | Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication |
title_sort | total burden of disease in cancer patients at diagnosis—a danish nationwide study of multimorbidity and redeemed medication |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493878/ https://www.ncbi.nlm.nih.gov/pubmed/32632149 http://dx.doi.org/10.1038/s41416-020-0950-3 |
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