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Proteolysis targeting chimeras (PROTACs) in cancer therapy

Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional structures consisting of a ligand that binds a protein to...

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Detalles Bibliográficos
Autores principales:	Ocaña, Alberto, Pandiella, Atanasio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493969/ https://www.ncbi.nlm.nih.gov/pubmed/32933565 http://dx.doi.org/10.1186/s13046-020-01672-1

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