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Proteolysis targeting chimeras (PROTACs) in cancer therapy
Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional structures consisting of a ligand that binds a protein to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493969/ https://www.ncbi.nlm.nih.gov/pubmed/32933565 http://dx.doi.org/10.1186/s13046-020-01672-1 |