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Elevated IL-6R on CD4(+) T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions

Th17 cells play vital role during pathogenesis of leprosy reactions. Previously, we have reported that IL-23 is involved in Th17 cells differentiation. Subsequently, our group also showed that IL-6 induces Th17 cell differentiation along with TGF-β in leprosy reactions. Here, we next asked the quest...

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Detalles Bibliográficos
Autores principales: Saini, Chaman, Srivastava, Rupesh K., Tarique, Mohd., Kurra, Santosh, Khanna, Neena, Ramesh, V., Sharma, Alpana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493991/
https://www.ncbi.nlm.nih.gov/pubmed/32934336
http://dx.doi.org/10.1038/s41598-020-72148-7