Cargando…

Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption

Osteoprotegerin (OPG) inhibits the ability of receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) to stimulate the differentiation, activity, and survival of bone-resorbing osteoclasts. Genetic studies in mice show that osteocytes are an important source of RANKL, but the cellular sources...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cawley, Keisha M., Bustamante-Gomez, Nancy Cecile, Guha, Anveshi G., MacLeod, Ryan S., Xiong, Jinhu, Gubrij, Igor, Liu, Yu, Mulkey, Robin, Palmieri, Michela, Thostenson, Jeff D., Goellner, Joseph J., O’Brien, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493998/ https://www.ncbi.nlm.nih.gov/pubmed/32905775 http://dx.doi.org/10.1016/j.celrep.2020.108052

Ejemplares similares

Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
por: Fu, Qiang, et al.
Publicado: (2023)

Effective CRISPR interference of an endogenous gene via a single transgene in mice
por: MacLeod, Ryan S., et al.
Publicado: (2019)

Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo
por: MacLeod, Ryan S., et al.
Publicado: (2021)

Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
por: Xiong, Jinhu, et al.
Publicado: (2018)

Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
por: Piemontese, Marilina, et al.
Publicado: (2016)

Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
por: Kim, Ha-Neui, et al.
Publicado: (2020)

IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligand
por: Guerra-Menéndez, Lucia, et al.
Publicado: (2013)

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
por: Xiong, Jinhu, et al.
Publicado: (2015)

Tramadol enhances PGF(2α)-stimulated osteoprotegerin synthesis in osteoblasts
por: Kim, Woo, et al.
Publicado: (2020)

Therapeutic targeting of osteoclasts by osteoprotegerin and bisphosphonates leads to a reduction of TNFalpha-mediated bone resorption
por: Redlich, K, et al.
Publicado: (2001)

Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds
por: Ren, Xiaoyan, et al.
Publicado: (2019)

(99)Tc-MDP-induced human osteoblast proliferation, differentiation and expression of osteoprotegerin
por: Chen, Jie, et al.
Publicado: (2017)

Osteoclastic bone resorption directly activates osteoblast function
por: Udagawa, Nobuyuki
Publicado: (2012)

Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL
por: Picarda, Gaëlle, et al.
Publicado: (2013)

Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro
por: Costa, Jessica L., et al.
Publicado: (2011)

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
por: Palmieri, Michela, et al.
Publicado: (2022)

Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass
por: Palmieri, Michela, et al.
Publicado: (2023)

Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts
Publicado: (1986)

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts
por: Fuller, Karen, et al.
Publicado: (1998)

Interleukin-19 promotes bone resorption by suppressing osteoprotegerin expression in BMSCs in a lipopolysaccharide-induced bone loss mouse model
por: Dai, Zhicheng, et al.
Publicado: (2023)

Down-Regulation by Resveratrol of Basic Fibroblast Growth Factor-Stimulated Osteoprotegerin Synthesis through Suppression of Akt in Osteoblasts
por: Kuroyanagi, Gen, et al.
Publicado: (2014)

Platelet-rich fibrin increases the osteoprotegerin/receptor activator of nuclear factor-κB ligand ratio in osteoblasts
por: Sumida, Ryuta, et al.
Publicado: (2019)

Eldecalcitol effects on osteoblastic differentiation and function in the presence or absence of osteoclastic bone resorption
por: Bu, Jie, et al.
Publicado: (2019)

Effect of gallium nitrate on the expression of osteoprotegerin and receptor activator of nuclear factor-κB ligand in osteoblasts in vivo and in vitro
por: LI, JINGWU, et al.
Publicado: (2016)

Osteoblast CFTR Inactivation Reduces Differentiation and Osteoprotegerin Expression in a Mouse Model of Cystic Fibrosis-Related Bone Disease
por: Stalvey, Michael S., et al.
Publicado: (2013)

Therapeutic implications of osteoprotegerin
por: Fili, Sofia, et al.
Publicado: (2009)

The role of osteoprotegerin in arthritis
por: Schett, Georg, et al.
Publicado: (2003)

Osteoprotegerin in Cardiometabolic Disorders
por: Pérez de Ciriza, C., et al.
Publicado: (2015)

Increased Osteoblastic Cxcl9 Contributes to the Uncoupled Bone Formation and Resorption in Postmenopausal Osteoporosis
por: Liu, Zezheng, et al.
Publicado: (2020)

B. abortus Infection Promotes an Imbalance in the Adipocyte–Osteoblast Crosstalk Favoring Bone Resorption
por: Freiberger, Rosa Nicole, et al.
Publicado: (2023)

OR27-02 The Bone Anabolic Effect Of An Antibody Blocking Oxidized Phospholipids Is Associated With An Increase In Wnt10b In Osteoblasts.
por: Palmieri, Michela, et al.
Publicado: (2023)

Expression of osteoprotegerin and osteoprotegerin ligand in giant cell tumor of bone and its clinical significance
por: YU, XIUCHUN, et al.
Publicado: (2013)

Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts
por: Ikeda, Kyoji, et al.
Publicado: (2014)

Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo
por: Uenaka, Maki, et al.
Publicado: (2022)

Biology of RANK, RANKL, and osteoprotegerin
por: Boyce, Brendan F, et al.
Publicado: (2007)

Staphylococcus aureus biofilms decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro
por: Sanchez, Carlos J, et al.
Publicado: (2013)

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia
por: Kuchimaru, Takahiro, et al.
Publicado: (2014)

Dual Effect of Chrysanthemum indicum Extract to Stimulate Osteoblast Differentiation and Inhibit Osteoclast Formation and Resorption In Vitro
por: Baek, Jong Min, et al.
Publicado: (2014)

Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption
por: Lee, So-Youn, et al.
Publicado: (2018)

Peptidomimetic inhibitors of L-plastin reduce the resorptive activity of osteoclast but not the bone forming activity of osteoblasts in vitro
por: Chellaiah, Meenakshi A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_b6enfjtg0ff67a7pgfd9kasv8a