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Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals

The risk of pesticide exposure in humans and animals may be magnified following natural and man-made disasters such as hurricanes and floods that can result in mobilization and redistribution of contaminated sediments. To develop broad-acting sorbents for mixtures of diverse toxins, we have processe...

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Autores principales: Wang, Meichen, Phillips, Timothy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494192/
https://www.ncbi.nlm.nih.gov/pubmed/32944385
http://dx.doi.org/10.3390/app9245325
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author Wang, Meichen
Phillips, Timothy D.
author_facet Wang, Meichen
Phillips, Timothy D.
author_sort Wang, Meichen
collection PubMed
description The risk of pesticide exposure in humans and animals may be magnified following natural and man-made disasters such as hurricanes and floods that can result in mobilization and redistribution of contaminated sediments. To develop broad-acting sorbents for mixtures of diverse toxins, we have processed calcium and sodium montmorillonite clays with high concentrations of sulfuric acid. These acid-processed montmorillonite clays (APMs) have shown limited hydration and swelling in water, higher surface areas, and lower trace metal levels than the parent clays, prior to processing. Isothermal analyses have indicated that newly developed APMs are highly active sorbents, with significantly increased binding capacities for a wide range of pesticides, including pentachlorophenol (PCP), 2,4,6-trichlorophenol (2,4,6-TCP), lindane, diazinon, linuron, trifluralin and paraquat. The safety and protective effects of APMs, against pesticide design mixtures, were confirmed in a living organism (Hydra vulgaris). Further work is planned to confirm the safety of the APMs in long-term rodent studies. This is the first report of a sorbent material (other than carbon) with high binding efficacy for mixtures of these pesticides. Based on our results, APMs (and similar clays), may be able to decrease human and animal pesticide exposures during disasters and emergencies.
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spelling pubmed-74941922020-09-16 Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals Wang, Meichen Phillips, Timothy D. Appl Sci (Basel) Article The risk of pesticide exposure in humans and animals may be magnified following natural and man-made disasters such as hurricanes and floods that can result in mobilization and redistribution of contaminated sediments. To develop broad-acting sorbents for mixtures of diverse toxins, we have processed calcium and sodium montmorillonite clays with high concentrations of sulfuric acid. These acid-processed montmorillonite clays (APMs) have shown limited hydration and swelling in water, higher surface areas, and lower trace metal levels than the parent clays, prior to processing. Isothermal analyses have indicated that newly developed APMs are highly active sorbents, with significantly increased binding capacities for a wide range of pesticides, including pentachlorophenol (PCP), 2,4,6-trichlorophenol (2,4,6-TCP), lindane, diazinon, linuron, trifluralin and paraquat. The safety and protective effects of APMs, against pesticide design mixtures, were confirmed in a living organism (Hydra vulgaris). Further work is planned to confirm the safety of the APMs in long-term rodent studies. This is the first report of a sorbent material (other than carbon) with high binding efficacy for mixtures of these pesticides. Based on our results, APMs (and similar clays), may be able to decrease human and animal pesticide exposures during disasters and emergencies. 2019-12-06 2019-12-02 /pmc/articles/PMC7494192/ /pubmed/32944385 http://dx.doi.org/10.3390/app9245325 Text en This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Meichen
Phillips, Timothy D.
Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals
title Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals
title_full Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals
title_fullStr Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals
title_full_unstemmed Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals
title_short Potential Applications of Clay-Based Therapy for the Reduction of Pesticide Exposures in Humans and Animals
title_sort potential applications of clay-based therapy for the reduction of pesticide exposures in humans and animals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494192/
https://www.ncbi.nlm.nih.gov/pubmed/32944385
http://dx.doi.org/10.3390/app9245325
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