Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China

BACKGROUND: RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported. METHODS AND RESULTS: Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla(OXA-...

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Detalles Bibliográficos
Autores principales: Shi, Qingyu, Han, Renru, Guo, Yan, Zheng, Yonggui, Yang, Yang, Yin, Dandan, Zhang, Rong, Hu, Fupin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494224/
https://www.ncbi.nlm.nih.gov/pubmed/32982327
http://dx.doi.org/10.2147/IDR.S257298
Descripción
Sumario:BACKGROUND: RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported. METHODS AND RESULTS: Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla(OXA-232) and bla(CTX-M-15). The rmtF gene was located on an IncFIB transformable plasmid of 128,536-bp and bla(OXA-232) was on a 6141-bp ColKP3 plasmid, respectively. CONCLUSION: Plasmids with rmtF found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing rmtF and bla(OXA-232) are gradually increasing in China.

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