Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China

BACKGROUND: RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported. METHODS AND RESULTS: Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla(OXA-...

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Autores principales: Shi, Qingyu, Han, Renru, Guo, Yan, Zheng, Yonggui, Yang, Yang, Yin, Dandan, Zhang, Rong, Hu, Fupin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494224/
https://www.ncbi.nlm.nih.gov/pubmed/32982327
http://dx.doi.org/10.2147/IDR.S257298
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author Shi, Qingyu
Han, Renru
Guo, Yan
Zheng, Yonggui
Yang, Yang
Yin, Dandan
Zhang, Rong
Hu, Fupin
author_facet Shi, Qingyu
Han, Renru
Guo, Yan
Zheng, Yonggui
Yang, Yang
Yin, Dandan
Zhang, Rong
Hu, Fupin
author_sort Shi, Qingyu
collection PubMed
description BACKGROUND: RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported. METHODS AND RESULTS: Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla(OXA-232) and bla(CTX-M-15). The rmtF gene was located on an IncFIB transformable plasmid of 128,536-bp and bla(OXA-232) was on a 6141-bp ColKP3 plasmid, respectively. CONCLUSION: Plasmids with rmtF found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing rmtF and bla(OXA-232) are gradually increasing in China.
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spelling pubmed-74942242020-09-24 Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China Shi, Qingyu Han, Renru Guo, Yan Zheng, Yonggui Yang, Yang Yin, Dandan Zhang, Rong Hu, Fupin Infect Drug Resist Short Report BACKGROUND: RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported. METHODS AND RESULTS: Three rmtF-positive Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced bla(OXA-232) and bla(CTX-M-15). The rmtF gene was located on an IncFIB transformable plasmid of 128,536-bp and bla(OXA-232) was on a 6141-bp ColKP3 plasmid, respectively. CONCLUSION: Plasmids with rmtF found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing rmtF and bla(OXA-232) are gradually increasing in China. Dove 2020-09-11 /pmc/articles/PMC7494224/ /pubmed/32982327 http://dx.doi.org/10.2147/IDR.S257298 Text en © 2020 Shi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Short Report
Shi, Qingyu
Han, Renru
Guo, Yan
Zheng, Yonggui
Yang, Yang
Yin, Dandan
Zhang, Rong
Hu, Fupin
Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China
title Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China
title_full Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China
title_fullStr Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China
title_full_unstemmed Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China
title_short Emergence of ST15 Klebsiella pneumoniae Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China
title_sort emergence of st15 klebsiella pneumoniae clinical isolates producing plasmids-mediated rmtf and oxa-232 in china
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494224/
https://www.ncbi.nlm.nih.gov/pubmed/32982327
http://dx.doi.org/10.2147/IDR.S257298
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