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Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4(+) and CD8(+) T cell and neutralizing antibody responses...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494270/ https://www.ncbi.nlm.nih.gov/pubmed/33010815 http://dx.doi.org/10.1016/j.cell.2020.09.038 |
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author | Rydyznski Moderbacher, Carolyn Ramirez, Sydney I. Dan, Jennifer M. Grifoni, Alba Hastie, Kathryn M. Weiskopf, Daniela Belanger, Simon Abbott, Robert K. Kim, Christina Choi, Jinyong Kato, Yu Crotty, Eleanor G. Kim, Cheryl Rawlings, Stephen A. Mateus, Jose Tse, Long Ping Victor Frazier, April Baric, Ralph Peters, Bjoern Greenbaum, Jason Ollmann Saphire, Erica Smith, Davey M. Sette, Alessandro Crotty, Shane |
author_facet | Rydyznski Moderbacher, Carolyn Ramirez, Sydney I. Dan, Jennifer M. Grifoni, Alba Hastie, Kathryn M. Weiskopf, Daniela Belanger, Simon Abbott, Robert K. Kim, Christina Choi, Jinyong Kato, Yu Crotty, Eleanor G. Kim, Cheryl Rawlings, Stephen A. Mateus, Jose Tse, Long Ping Victor Frazier, April Baric, Ralph Peters, Bjoern Greenbaum, Jason Ollmann Saphire, Erica Smith, Davey M. Sette, Alessandro Crotty, Shane |
author_sort | Rydyznski Moderbacher, Carolyn |
collection | PubMed |
description | Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4(+) and CD8(+) T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4(+) and CD8(+) T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4(+) and CD8(+) T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals ≥ 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that coordinated CD4(+) T cell, CD8(+) T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2. |
format | Online Article Text |
id | pubmed-7494270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74942702020-09-17 Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity Rydyznski Moderbacher, Carolyn Ramirez, Sydney I. Dan, Jennifer M. Grifoni, Alba Hastie, Kathryn M. Weiskopf, Daniela Belanger, Simon Abbott, Robert K. Kim, Christina Choi, Jinyong Kato, Yu Crotty, Eleanor G. Kim, Cheryl Rawlings, Stephen A. Mateus, Jose Tse, Long Ping Victor Frazier, April Baric, Ralph Peters, Bjoern Greenbaum, Jason Ollmann Saphire, Erica Smith, Davey M. Sette, Alessandro Crotty, Shane Cell Article Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4(+) and CD8(+) T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4(+) and CD8(+) T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4(+) and CD8(+) T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals ≥ 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that coordinated CD4(+) T cell, CD8(+) T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2. Cell Press 2020-11-12 /pmc/articles/PMC7494270/ /pubmed/33010815 http://dx.doi.org/10.1016/j.cell.2020.09.038 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rydyznski Moderbacher, Carolyn Ramirez, Sydney I. Dan, Jennifer M. Grifoni, Alba Hastie, Kathryn M. Weiskopf, Daniela Belanger, Simon Abbott, Robert K. Kim, Christina Choi, Jinyong Kato, Yu Crotty, Eleanor G. Kim, Cheryl Rawlings, Stephen A. Mateus, Jose Tse, Long Ping Victor Frazier, April Baric, Ralph Peters, Bjoern Greenbaum, Jason Ollmann Saphire, Erica Smith, Davey M. Sette, Alessandro Crotty, Shane Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity |
title | Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity |
title_full | Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity |
title_fullStr | Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity |
title_full_unstemmed | Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity |
title_short | Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity |
title_sort | antigen-specific adaptive immunity to sars-cov-2 in acute covid-19 and associations with age and disease severity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494270/ https://www.ncbi.nlm.nih.gov/pubmed/33010815 http://dx.doi.org/10.1016/j.cell.2020.09.038 |
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