Cargando…

Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease

The coronavirus disease 2019 (COVID-19) virus has spread all over the world. Scientists are trying to discover drugs as effective treatment for patients with COVID-19. So far about 30 drugs have been introduced that one of them is Tocilizumab. Recently Tocilizumab has been introduced to treat patien...

Descripción completa

Detalles Bibliográficos
Autores principales: Samaee, Hamidreza, Mohsenzadegan, Monireh, Ala, Shahram, Maroufi, Shahnam Sedigh, Moradimajd, Parisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494278/
https://www.ncbi.nlm.nih.gov/pubmed/33045577
http://dx.doi.org/10.1016/j.intimp.2020.107018
_version_ 1783582715295039488
author Samaee, Hamidreza
Mohsenzadegan, Monireh
Ala, Shahram
Maroufi, Shahnam Sedigh
Moradimajd, Parisa
author_facet Samaee, Hamidreza
Mohsenzadegan, Monireh
Ala, Shahram
Maroufi, Shahnam Sedigh
Moradimajd, Parisa
author_sort Samaee, Hamidreza
collection PubMed
description The coronavirus disease 2019 (COVID-19) virus has spread all over the world. Scientists are trying to discover drugs as effective treatment for patients with COVID-19. So far about 30 drugs have been introduced that one of them is Tocilizumab. Recently Tocilizumab has been introduced to treat patients with COVID-19 and researchers are investigating further the efficacy of this drug for different are patients. In Iran and China, some reports showed a positive effect of Tocilizumab on Saturation of Peripheral Oxygen (SPO2) but results of CT scan in patients in different. In some patients, CT scan showed reduced infiltration, however in other no change was observed. Unfortunately, until now there has been no definitive and effective treatment for patients with COVID-19. Although Tocilizumab has been accepted by China Health Commission to treat infected patients, its positive effects still cannot be predicted in all patients. Based on evidence of the Tocilizumab’s effect on the SARS COV 2, researchers hope this drug will make effective and promising treatment to improve lung tissue inflammation in patients with the fatal COVID-19 virus. The present study provides an overview of respiratory inflammation with COVID-19 and probable effect of Tocilizumab on SARS-COV 2.
format Online
Article
Text
id pubmed-7494278
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-74942782020-09-17 Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease Samaee, Hamidreza Mohsenzadegan, Monireh Ala, Shahram Maroufi, Shahnam Sedigh Moradimajd, Parisa Int Immunopharmacol Article The coronavirus disease 2019 (COVID-19) virus has spread all over the world. Scientists are trying to discover drugs as effective treatment for patients with COVID-19. So far about 30 drugs have been introduced that one of them is Tocilizumab. Recently Tocilizumab has been introduced to treat patients with COVID-19 and researchers are investigating further the efficacy of this drug for different are patients. In Iran and China, some reports showed a positive effect of Tocilizumab on Saturation of Peripheral Oxygen (SPO2) but results of CT scan in patients in different. In some patients, CT scan showed reduced infiltration, however in other no change was observed. Unfortunately, until now there has been no definitive and effective treatment for patients with COVID-19. Although Tocilizumab has been accepted by China Health Commission to treat infected patients, its positive effects still cannot be predicted in all patients. Based on evidence of the Tocilizumab’s effect on the SARS COV 2, researchers hope this drug will make effective and promising treatment to improve lung tissue inflammation in patients with the fatal COVID-19 virus. The present study provides an overview of respiratory inflammation with COVID-19 and probable effect of Tocilizumab on SARS-COV 2. Elsevier B.V. 2020-12 2020-09-16 /pmc/articles/PMC7494278/ /pubmed/33045577 http://dx.doi.org/10.1016/j.intimp.2020.107018 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Samaee, Hamidreza
Mohsenzadegan, Monireh
Ala, Shahram
Maroufi, Shahnam Sedigh
Moradimajd, Parisa
Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease
title Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease
title_full Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease
title_fullStr Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease
title_full_unstemmed Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease
title_short Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease
title_sort tocilizumab for treatment patients with covid-19: recommended medication for novel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494278/
https://www.ncbi.nlm.nih.gov/pubmed/33045577
http://dx.doi.org/10.1016/j.intimp.2020.107018
work_keys_str_mv AT samaeehamidreza tocilizumabfortreatmentpatientswithcovid19recommendedmedicationfornoveldisease
AT mohsenzadeganmonireh tocilizumabfortreatmentpatientswithcovid19recommendedmedicationfornoveldisease
AT alashahram tocilizumabfortreatmentpatientswithcovid19recommendedmedicationfornoveldisease
AT maroufishahnamsedigh tocilizumabfortreatmentpatientswithcovid19recommendedmedicationfornoveldisease
AT moradimajdparisa tocilizumabfortreatmentpatientswithcovid19recommendedmedicationfornoveldisease