Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion

Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, b...

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Autores principales: Belizaire, Roger, Makar, Robert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494440/
https://www.ncbi.nlm.nih.gov/pubmed/33129606
http://dx.doi.org/10.1016/j.tmrv.2020.09.002
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author Belizaire, Roger
Makar, Robert S
author_facet Belizaire, Roger
Makar, Robert S
author_sort Belizaire, Roger
collection PubMed
description Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, but are a consequence of platelet sequestration and consumption. This review summarizes the clinical factors that result in platelet refractoriness and highlights recent data describing novel biological mechanisms that contribute to this clinical problem.
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spelling pubmed-74944402020-09-17 Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion Belizaire, Roger Makar, Robert S Transfus Med Rev Article Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, but are a consequence of platelet sequestration and consumption. This review summarizes the clinical factors that result in platelet refractoriness and highlights recent data describing novel biological mechanisms that contribute to this clinical problem. Published by Elsevier Inc. 2020-10 2020-09-17 /pmc/articles/PMC7494440/ /pubmed/33129606 http://dx.doi.org/10.1016/j.tmrv.2020.09.002 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Belizaire, Roger
Makar, Robert S
Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
title Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
title_full Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
title_fullStr Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
title_full_unstemmed Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
title_short Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion
title_sort non-alloimmune mechanisms of thrombocytopenia and refractoriness to platelet transfusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494440/
https://www.ncbi.nlm.nih.gov/pubmed/33129606
http://dx.doi.org/10.1016/j.tmrv.2020.09.002
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