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A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms

Stimulator of interferon genes (STING), as a signaling hub in innate immunity, plays a central role for the effective initiation of host defense mechanisms against microbial infections. Upon binding of its ligand cyclic dinucleotides (CDNs) produced by the cyclic GMP-AMP synthase (cGAS) or invading...

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Detalles Bibliográficos
Autores principales:	Zhu, Qingyuan, Hu, Hui, Liu, Haixia, Shen, Hong, Yan, Zhipeng, Gao, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494516/ https://www.ncbi.nlm.nih.gov/pubmed/32949635 http://dx.doi.org/10.1016/j.antiviral.2020.104933

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