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Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with fem...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494587/ https://www.ncbi.nlm.nih.gov/pubmed/32983904 http://dx.doi.org/10.1016/j.toxrep.2020.08.005 |
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author | Mazzocco, John C. Jagadapillai, Rekha Gozal, Evelyne Kong, Maiying Xu, Qian Barnes, Gregory N. Freedman, Jonathan H. |
author_facet | Mazzocco, John C. Jagadapillai, Rekha Gozal, Evelyne Kong, Maiying Xu, Qian Barnes, Gregory N. Freedman, Jonathan H. |
author_sort | Mazzocco, John C. |
collection | PubMed |
description | Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with female animals accumulating more metal than males (p < 0.001). Both genders fed a high fat diet showed significant increases in cadmium levels compared to low fat diet fed mice (p < 0.001). Cadmium and high fat diet significantly affected the levels of several essential metals, including magnesium, potassium, chromium, iron, cobalt, copper, zinc and selenium. Additionally, these treatments resulted in increased superoxide levels within the cortex, amygdala and hippocampus. These findings support a model where cadmium and high fat diet affect the levels of redox-active, essential metal homeostasis. This phenomenon may contribute to the underlying mechanism(s) responsible for the development of neurocognitive disorders. |
format | Online Article Text |
id | pubmed-7494587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74945872020-09-24 Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet Mazzocco, John C. Jagadapillai, Rekha Gozal, Evelyne Kong, Maiying Xu, Qian Barnes, Gregory N. Freedman, Jonathan H. Toxicol Rep Regular Article Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with female animals accumulating more metal than males (p < 0.001). Both genders fed a high fat diet showed significant increases in cadmium levels compared to low fat diet fed mice (p < 0.001). Cadmium and high fat diet significantly affected the levels of several essential metals, including magnesium, potassium, chromium, iron, cobalt, copper, zinc and selenium. Additionally, these treatments resulted in increased superoxide levels within the cortex, amygdala and hippocampus. These findings support a model where cadmium and high fat diet affect the levels of redox-active, essential metal homeostasis. This phenomenon may contribute to the underlying mechanism(s) responsible for the development of neurocognitive disorders. Elsevier 2020-08-23 /pmc/articles/PMC7494587/ /pubmed/32983904 http://dx.doi.org/10.1016/j.toxrep.2020.08.005 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Mazzocco, John C. Jagadapillai, Rekha Gozal, Evelyne Kong, Maiying Xu, Qian Barnes, Gregory N. Freedman, Jonathan H. Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
title | Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
title_full | Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
title_fullStr | Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
title_full_unstemmed | Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
title_short | Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
title_sort | disruption of essential metal homeostasis in the brain by cadmium and high-fat diet |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494587/ https://www.ncbi.nlm.nih.gov/pubmed/32983904 http://dx.doi.org/10.1016/j.toxrep.2020.08.005 |
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