Cargando…

Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet

Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with fem...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazzocco, John C., Jagadapillai, Rekha, Gozal, Evelyne, Kong, Maiying, Xu, Qian, Barnes, Gregory N., Freedman, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494587/
https://www.ncbi.nlm.nih.gov/pubmed/32983904
http://dx.doi.org/10.1016/j.toxrep.2020.08.005
_version_ 1783582769068113920
author Mazzocco, John C.
Jagadapillai, Rekha
Gozal, Evelyne
Kong, Maiying
Xu, Qian
Barnes, Gregory N.
Freedman, Jonathan H.
author_facet Mazzocco, John C.
Jagadapillai, Rekha
Gozal, Evelyne
Kong, Maiying
Xu, Qian
Barnes, Gregory N.
Freedman, Jonathan H.
author_sort Mazzocco, John C.
collection PubMed
description Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with female animals accumulating more metal than males (p < 0.001). Both genders fed a high fat diet showed significant increases in cadmium levels compared to low fat diet fed mice (p < 0.001). Cadmium and high fat diet significantly affected the levels of several essential metals, including magnesium, potassium, chromium, iron, cobalt, copper, zinc and selenium. Additionally, these treatments resulted in increased superoxide levels within the cortex, amygdala and hippocampus. These findings support a model where cadmium and high fat diet affect the levels of redox-active, essential metal homeostasis. This phenomenon may contribute to the underlying mechanism(s) responsible for the development of neurocognitive disorders.
format Online
Article
Text
id pubmed-7494587
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-74945872020-09-24 Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet Mazzocco, John C. Jagadapillai, Rekha Gozal, Evelyne Kong, Maiying Xu, Qian Barnes, Gregory N. Freedman, Jonathan H. Toxicol Rep Regular Article Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with female animals accumulating more metal than males (p < 0.001). Both genders fed a high fat diet showed significant increases in cadmium levels compared to low fat diet fed mice (p < 0.001). Cadmium and high fat diet significantly affected the levels of several essential metals, including magnesium, potassium, chromium, iron, cobalt, copper, zinc and selenium. Additionally, these treatments resulted in increased superoxide levels within the cortex, amygdala and hippocampus. These findings support a model where cadmium and high fat diet affect the levels of redox-active, essential metal homeostasis. This phenomenon may contribute to the underlying mechanism(s) responsible for the development of neurocognitive disorders. Elsevier 2020-08-23 /pmc/articles/PMC7494587/ /pubmed/32983904 http://dx.doi.org/10.1016/j.toxrep.2020.08.005 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Mazzocco, John C.
Jagadapillai, Rekha
Gozal, Evelyne
Kong, Maiying
Xu, Qian
Barnes, Gregory N.
Freedman, Jonathan H.
Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
title Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
title_full Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
title_fullStr Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
title_full_unstemmed Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
title_short Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
title_sort disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494587/
https://www.ncbi.nlm.nih.gov/pubmed/32983904
http://dx.doi.org/10.1016/j.toxrep.2020.08.005
work_keys_str_mv AT mazzoccojohnc disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet
AT jagadapillairekha disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet
AT gozalevelyne disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet
AT kongmaiying disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet
AT xuqian disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet
AT barnesgregoryn disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet
AT freedmanjonathanh disruptionofessentialmetalhomeostasisinthebrainbycadmiumandhighfatdiet