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Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy

Atypical meningioma (AM) (WHO-II) has a recurrence rate of 28% after gross total resection (GTR) with limited salvage options. Transarterial therapies may provide treatment opportunities in AM patients who exhausted standard-of-care therapy. In cases where favorable tumor vasculature and particle si...

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Autores principales: Toskich, Beau B., Muneer, Mohamed S., Gopal, Neethu, Akinduro, Oluwaseun O., Marenco-Hillembrand, Lina, Ritchie, Charles, Miller, David A., Middlebrooks, Erik H., Tawk, Rabih G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494606/
https://www.ncbi.nlm.nih.gov/pubmed/32983300
http://dx.doi.org/10.1016/j.radcr.2020.07.051
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author Toskich, Beau B.
Muneer, Mohamed S.
Gopal, Neethu
Akinduro, Oluwaseun O.
Marenco-Hillembrand, Lina
Ritchie, Charles
Miller, David A.
Middlebrooks, Erik H.
Tawk, Rabih G.
author_facet Toskich, Beau B.
Muneer, Mohamed S.
Gopal, Neethu
Akinduro, Oluwaseun O.
Marenco-Hillembrand, Lina
Ritchie, Charles
Miller, David A.
Middlebrooks, Erik H.
Tawk, Rabih G.
author_sort Toskich, Beau B.
collection PubMed
description Atypical meningioma (AM) (WHO-II) has a recurrence rate of 28% after gross total resection (GTR) with limited salvage options. Transarterial therapies may provide treatment opportunities in AM patients who exhausted standard-of-care therapy. In cases where favorable tumor vasculature and particle simulation demonstrate acceptable target dose, Yttrium-90 trans-arterial radioemobilization (TARE) could theoretically provide salvage therapy. A 67-year-old man presented with recurrent AM post gross total resection with adjuvant radiotherapy in 2012, 2014, and 2016. The patient was deemed a poor candidate for additional therapies. Tumor vasculature mapping was performed to determine TARE candidacy. Super-selective angiography and contrast-enhanced cone-beam computed tomography angiosomes demonstrated predominant pial collaterals and minor supply from a middle meningeal artery branch. Particle simulation was performed by infusing 0.3 mCi of 99mTc-macroaggregated albumin (99mTc-MAA). SPECT/CT-MRI fusion demonstrated conformal activity solely within the tumor volume perfused by the middle meningeal artery branch with a lung shunt fraction of 54.7%. The patient subsequently received off-label Nivolumab (PD-1 inhibitor). Mapping angiography for AM using 99mTc-MAA is feasible. It may identify candidates for TARE and potential AM patients with favorable blood supply. The potential for conformal intracranial vascular brachytherapy is intriguing, however, altered arterial supply in recurrent tumors is challenging.
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spelling pubmed-74946062020-09-24 Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy Toskich, Beau B. Muneer, Mohamed S. Gopal, Neethu Akinduro, Oluwaseun O. Marenco-Hillembrand, Lina Ritchie, Charles Miller, David A. Middlebrooks, Erik H. Tawk, Rabih G. Radiol Case Rep Case Report Atypical meningioma (AM) (WHO-II) has a recurrence rate of 28% after gross total resection (GTR) with limited salvage options. Transarterial therapies may provide treatment opportunities in AM patients who exhausted standard-of-care therapy. In cases where favorable tumor vasculature and particle simulation demonstrate acceptable target dose, Yttrium-90 trans-arterial radioemobilization (TARE) could theoretically provide salvage therapy. A 67-year-old man presented with recurrent AM post gross total resection with adjuvant radiotherapy in 2012, 2014, and 2016. The patient was deemed a poor candidate for additional therapies. Tumor vasculature mapping was performed to determine TARE candidacy. Super-selective angiography and contrast-enhanced cone-beam computed tomography angiosomes demonstrated predominant pial collaterals and minor supply from a middle meningeal artery branch. Particle simulation was performed by infusing 0.3 mCi of 99mTc-macroaggregated albumin (99mTc-MAA). SPECT/CT-MRI fusion demonstrated conformal activity solely within the tumor volume perfused by the middle meningeal artery branch with a lung shunt fraction of 54.7%. The patient subsequently received off-label Nivolumab (PD-1 inhibitor). Mapping angiography for AM using 99mTc-MAA is feasible. It may identify candidates for TARE and potential AM patients with favorable blood supply. The potential for conformal intracranial vascular brachytherapy is intriguing, however, altered arterial supply in recurrent tumors is challenging. Elsevier 2020-09-11 /pmc/articles/PMC7494606/ /pubmed/32983300 http://dx.doi.org/10.1016/j.radcr.2020.07.051 Text en © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Toskich, Beau B.
Muneer, Mohamed S.
Gopal, Neethu
Akinduro, Oluwaseun O.
Marenco-Hillembrand, Lina
Ritchie, Charles
Miller, David A.
Middlebrooks, Erik H.
Tawk, Rabih G.
Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
title Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
title_full Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
title_fullStr Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
title_full_unstemmed Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
title_short Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
title_sort mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494606/
https://www.ncbi.nlm.nih.gov/pubmed/32983300
http://dx.doi.org/10.1016/j.radcr.2020.07.051
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