Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host

Human schistosomiasis, which is caused by schistosomes, is a zoonosis that is difficult to control because of the many reservoir hosts. However, Microtus fortis is the only mammal that is naturally resistant to Schistosoma japonicum infection known in China, in which S. japonicum growth and developm...

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Autores principales: Shen, Jia, Xiang, Suoyu, Peng, Mei, Zhou, Zhijun, Wu, Zhongdao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494751/
https://www.ncbi.nlm.nih.gov/pubmed/33013763
http://dx.doi.org/10.3389/fmicb.2020.02092
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author Shen, Jia
Xiang, Suoyu
Peng, Mei
Zhou, Zhijun
Wu, Zhongdao
author_facet Shen, Jia
Xiang, Suoyu
Peng, Mei
Zhou, Zhijun
Wu, Zhongdao
author_sort Shen, Jia
collection PubMed
description Human schistosomiasis, which is caused by schistosomes, is a zoonosis that is difficult to control because of the many reservoir hosts. However, Microtus fortis is the only mammal that is naturally resistant to Schistosoma japonicum infection known in China, in which S. japonicum growth and development were arrested on day 12, and the worms eliminated on day 20 post-infection. In this review, we present an overview of the established and purported mechanisms of resistance to S. japonicum infection in M. fortis in comparison to Rattus norvegicus, a semi-permissive host. Clarifying the mechanism of this efficient resistance can help us to better understand host-parasite interaction and to provide better methods to control schistosomiasis.
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spelling pubmed-74947512020-10-02 Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host Shen, Jia Xiang, Suoyu Peng, Mei Zhou, Zhijun Wu, Zhongdao Front Microbiol Microbiology Human schistosomiasis, which is caused by schistosomes, is a zoonosis that is difficult to control because of the many reservoir hosts. However, Microtus fortis is the only mammal that is naturally resistant to Schistosoma japonicum infection known in China, in which S. japonicum growth and development were arrested on day 12, and the worms eliminated on day 20 post-infection. In this review, we present an overview of the established and purported mechanisms of resistance to S. japonicum infection in M. fortis in comparison to Rattus norvegicus, a semi-permissive host. Clarifying the mechanism of this efficient resistance can help us to better understand host-parasite interaction and to provide better methods to control schistosomiasis. Frontiers Media S.A. 2020-09-03 /pmc/articles/PMC7494751/ /pubmed/33013763 http://dx.doi.org/10.3389/fmicb.2020.02092 Text en Copyright © 2020 Shen, Xiang, Peng, Zhou and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Shen, Jia
Xiang, Suoyu
Peng, Mei
Zhou, Zhijun
Wu, Zhongdao
Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
title Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
title_full Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
title_fullStr Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
title_full_unstemmed Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
title_short Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
title_sort mechanisms of resistance to schistosoma japonicum infection in microtus fortis, the natural non-permissive host
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494751/
https://www.ncbi.nlm.nih.gov/pubmed/33013763
http://dx.doi.org/10.3389/fmicb.2020.02092
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