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Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

OBJECTIVE: The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mutations and BRCA1 methylation in women with OC. ME...

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Detalles Bibliográficos
Autores principales:	Kalachand, Roshni D., O’Riain, Ciaran, Toomey, Sinead, Carr, Aoife, Timms, Kirsten M., O’Toole, Sharon, Madden, Stephen, Bates, Mark, O’Leary, John J., Gleeson, Noreen, O’Donnell, Dearbhaile, Grogan, Liam, Breathnach, Oscar, Farrelly, Angela, Stordal, Britta, Hennessy, Bryan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society of Obstetrics and Gynecology 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494761/ https://www.ncbi.nlm.nih.gov/pubmed/32872764 http://dx.doi.org/10.5468/ogs.20033

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