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Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study
INTRODUCTION: keratoconus is a common disease in the general population, with prevalence ranging up to 200 per 100 000 with a reported increase in Saudi Arabia. Collagen Cross-Linkage is now an established treatment in isolation and in conjunction with other modalities for managing keratoconus. Our...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494823/ https://www.ncbi.nlm.nih.gov/pubmed/32983439 http://dx.doi.org/10.1016/j.amsu.2020.09.010 |
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author | Bamahfouz, Ashjan Jouhargy, Serene Basheikh, Ahmed Alqahtani, Nawaf Elhams, Yaser Aldosari, Ayat Khattab, Faisal Alkhoutani, Ensa Alfaqih, Khadija |
author_facet | Bamahfouz, Ashjan Jouhargy, Serene Basheikh, Ahmed Alqahtani, Nawaf Elhams, Yaser Aldosari, Ayat Khattab, Faisal Alkhoutani, Ensa Alfaqih, Khadija |
author_sort | Bamahfouz, Ashjan |
collection | PubMed |
description | INTRODUCTION: keratoconus is a common disease in the general population, with prevalence ranging up to 200 per 100 000 with a reported increase in Saudi Arabia. Collagen Cross-Linkage is now an established treatment in isolation and in conjunction with other modalities for managing keratoconus. Our aim is to evaluate using a cohort study the impact of the treatment over a course of 18 months. METHODS: To evaluate the impact of 18 months after collagen cross-linkage treatment and its determinants in eyes with keratoconus in Western Saudi Arabia. A one-armed prospective cohort study design on 45 patients with Stage I, II, III and IV keratoconus who were treated by Collagen Cross-Linkage modality was developed at our institute between 2018 and 2019 to establish the success rate of corneal ectasia stabilization of the disease. RESULTS: Demographic data and grades of keratoconus (Amsler - Krumiech classification) at presentation were correlated to changes in corneal parameters 18 months after CXL compared to that at presentation. Stage I, II, III and IV keratoconus were 13, 14, 2 and 16 eyes respectively. The study showed that the K max significantly declined (P = 0.05) while spherical equivalent refractive status changed from median −1.5D to −2.27D (P = 0.002). Meanwhile, Central corneal thickness significantly reduced (P = 0.001). CONCLUSION: CXL can prove to be efficient in the treatment of Keratoconus and more studies should study ways to improve and implement this treatment plan to such patients. |
format | Online Article Text |
id | pubmed-7494823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74948232020-09-24 Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study Bamahfouz, Ashjan Jouhargy, Serene Basheikh, Ahmed Alqahtani, Nawaf Elhams, Yaser Aldosari, Ayat Khattab, Faisal Alkhoutani, Ensa Alfaqih, Khadija Ann Med Surg (Lond) Cohort Study INTRODUCTION: keratoconus is a common disease in the general population, with prevalence ranging up to 200 per 100 000 with a reported increase in Saudi Arabia. Collagen Cross-Linkage is now an established treatment in isolation and in conjunction with other modalities for managing keratoconus. Our aim is to evaluate using a cohort study the impact of the treatment over a course of 18 months. METHODS: To evaluate the impact of 18 months after collagen cross-linkage treatment and its determinants in eyes with keratoconus in Western Saudi Arabia. A one-armed prospective cohort study design on 45 patients with Stage I, II, III and IV keratoconus who were treated by Collagen Cross-Linkage modality was developed at our institute between 2018 and 2019 to establish the success rate of corneal ectasia stabilization of the disease. RESULTS: Demographic data and grades of keratoconus (Amsler - Krumiech classification) at presentation were correlated to changes in corneal parameters 18 months after CXL compared to that at presentation. Stage I, II, III and IV keratoconus were 13, 14, 2 and 16 eyes respectively. The study showed that the K max significantly declined (P = 0.05) while spherical equivalent refractive status changed from median −1.5D to −2.27D (P = 0.002). Meanwhile, Central corneal thickness significantly reduced (P = 0.001). CONCLUSION: CXL can prove to be efficient in the treatment of Keratoconus and more studies should study ways to improve and implement this treatment plan to such patients. Elsevier 2020-09-09 /pmc/articles/PMC7494823/ /pubmed/32983439 http://dx.doi.org/10.1016/j.amsu.2020.09.010 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Cohort Study Bamahfouz, Ashjan Jouhargy, Serene Basheikh, Ahmed Alqahtani, Nawaf Elhams, Yaser Aldosari, Ayat Khattab, Faisal Alkhoutani, Ensa Alfaqih, Khadija Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study |
title | Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study |
title_full | Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study |
title_fullStr | Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study |
title_full_unstemmed | Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study |
title_short | Corneal parameters 18 Months following collagen cross-linkage treatment (CXL) for keratoconus in western Saudi Arabia: A prospective cohort study |
title_sort | corneal parameters 18 months following collagen cross-linkage treatment (cxl) for keratoconus in western saudi arabia: a prospective cohort study |
topic | Cohort Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494823/ https://www.ncbi.nlm.nih.gov/pubmed/32983439 http://dx.doi.org/10.1016/j.amsu.2020.09.010 |
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