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PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast–osteoblast uncoupling

PKC-δ is an important molecule for B-cell proliferation and tolerance. B cells have long been recognized to play a part in osteoimmunology and pathological bone loss. However, the role of B cells with PKC-δ deficiency in bone homeostasis and the underlying mechanisms are unknown. We generated mice w...

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Detalles Bibliográficos
Autores principales:	Li, Shangfu, Liu, Qiuli, Wu, Depeng, He, Tianwei, Yuan, Jinbo, Qiu, Heng, Tickner, Jennifer, Zheng, Song Guo, Li, Xiaojuan, Xu, Jiake, Rong, Limin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494897/ https://www.ncbi.nlm.nih.gov/pubmed/32938907 http://dx.doi.org/10.1038/s41419-020-02947-3

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