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A membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent

Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum–acridine anticancer agent (compound 1), a correlati...

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Detalles Bibliográficos
Autores principales: Yao, Xiyuan, Watkins, Noah H., Brown-Harding, Heather, Bierbach, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494928/
https://www.ncbi.nlm.nih.gov/pubmed/32939009
http://dx.doi.org/10.1038/s41598-020-72099-z