IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

Cardiorenal syndrome type 4 (CRS4) is a common complication of chronic kidney disease (CKD), but the pathogenic mechanisms remain elusive. Here we report that morphological and functional changes in myocardial mitochondria are observed in CKD mice, especially decreases in oxidative phosphorylation a...

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Detalles Bibliográficos
Autores principales: Huang, Yinghui, Wang, Shaobo, Zhou, Jie, Liu, Yong, Du, Changhong, Yang, Ke, Bi, Xianjin, Liu, Mingying, Han, Wenhao, Wang, Kailong, Xiong, Jiachuan, Wang, Song, Wang, Yue, Nie, Ling, Liu, Chi, Zhang, Daohai, Gu, Jun, Zeng, Chunyu, Zhao, Jinghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494935/
https://www.ncbi.nlm.nih.gov/pubmed/32938919
http://dx.doi.org/10.1038/s41467-020-18519-0

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