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Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis

Background: Galectin-3 may predict mortality for patients with aortic stenosis (AS) after transcatheter aortic valve replacement (TAVR). However, the results were inconsistent. We aimed to evaluate the association between baseline galectin and mortality after TAVR in a meta-analysis. Methods: Relate...

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Autores principales: Zhang, Hong-liang, Song, Guang-yuan, Zhao, Jie, Wang, Yu-bin, Wang, Mo-yang, Xu, Yan-lu, Wang, Bin-cheng, Niu, Guan-nan, Liu, Zhi-hong, Wu, Yong-jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494980/
https://www.ncbi.nlm.nih.gov/pubmed/32893848
http://dx.doi.org/10.1042/BSR20202306
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author Zhang, Hong-liang
Song, Guang-yuan
Zhao, Jie
Wang, Yu-bin
Wang, Mo-yang
Xu, Yan-lu
Wang, Bin-cheng
Niu, Guan-nan
Liu, Zhi-hong
Wu, Yong-jian
author_facet Zhang, Hong-liang
Song, Guang-yuan
Zhao, Jie
Wang, Yu-bin
Wang, Mo-yang
Xu, Yan-lu
Wang, Bin-cheng
Niu, Guan-nan
Liu, Zhi-hong
Wu, Yong-jian
author_sort Zhang, Hong-liang
collection PubMed
description Background: Galectin-3 may predict mortality for patients with aortic stenosis (AS) after transcatheter aortic valve replacement (TAVR). However, the results were inconsistent. We aimed to evaluate the association between baseline galectin and mortality after TAVR in a meta-analysis. Methods: Related follow-up studies were obtained by systematic search of PubMed, Cochrane’s Library, and Embase databases. Both the fixed- and the random-effect models were used for the meta-analysis. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcome. Results: Five prospective cohort studies with 854 patients were included, with a follow-up period between 1 and 1.9 years. Patients with higher baseline circulating galectin-3 had an increased risk of all-cause mortality after TAVR (random-effects model: risk ratio [RR]: 1.63, 95% confidence interval [CI]: 1.19–2.23, P=0.002; fixed-effects model: RR: 1.62, 95% CI: 1.19–2.20, P=0.002; I(2) = 4%). Adjustment of estimated glomerular filtration rate (RR: 1.73, P=0.02) or B-type natriuretic peptide (BNP) or N-terminal pro-BNP (RR: 1.83, P=0.02) did not significantly affect the result. A trend of stronger association between higher baseline circulating galectin-3 and increased risk of all-cause mortality after TAVR was observed in studies with an enzyme-linked fluorescent assay (ELFA) (RR: 3.04, P=0.003) compared with those with an enzyme-linked immunosorbent assay (ELISA) (RR: 1.42, P=0.04; P for subgroup difference =0.06). Conclusion: Higher circulating galectin-3 before the procedure may predict all-cause mortality of AS patients after TAVR.
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spelling pubmed-74949802020-09-24 Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis Zhang, Hong-liang Song, Guang-yuan Zhao, Jie Wang, Yu-bin Wang, Mo-yang Xu, Yan-lu Wang, Bin-cheng Niu, Guan-nan Liu, Zhi-hong Wu, Yong-jian Biosci Rep Pharmacology & Toxicology Background: Galectin-3 may predict mortality for patients with aortic stenosis (AS) after transcatheter aortic valve replacement (TAVR). However, the results were inconsistent. We aimed to evaluate the association between baseline galectin and mortality after TAVR in a meta-analysis. Methods: Related follow-up studies were obtained by systematic search of PubMed, Cochrane’s Library, and Embase databases. Both the fixed- and the random-effect models were used for the meta-analysis. Subgroup analyses were performed to evaluate the influences of study characteristics on the outcome. Results: Five prospective cohort studies with 854 patients were included, with a follow-up period between 1 and 1.9 years. Patients with higher baseline circulating galectin-3 had an increased risk of all-cause mortality after TAVR (random-effects model: risk ratio [RR]: 1.63, 95% confidence interval [CI]: 1.19–2.23, P=0.002; fixed-effects model: RR: 1.62, 95% CI: 1.19–2.20, P=0.002; I(2) = 4%). Adjustment of estimated glomerular filtration rate (RR: 1.73, P=0.02) or B-type natriuretic peptide (BNP) or N-terminal pro-BNP (RR: 1.83, P=0.02) did not significantly affect the result. A trend of stronger association between higher baseline circulating galectin-3 and increased risk of all-cause mortality after TAVR was observed in studies with an enzyme-linked fluorescent assay (ELFA) (RR: 3.04, P=0.003) compared with those with an enzyme-linked immunosorbent assay (ELISA) (RR: 1.42, P=0.04; P for subgroup difference =0.06). Conclusion: Higher circulating galectin-3 before the procedure may predict all-cause mortality of AS patients after TAVR. Portland Press Ltd. 2020-09-16 /pmc/articles/PMC7494980/ /pubmed/32893848 http://dx.doi.org/10.1042/BSR20202306 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Pharmacology & Toxicology
Zhang, Hong-liang
Song, Guang-yuan
Zhao, Jie
Wang, Yu-bin
Wang, Mo-yang
Xu, Yan-lu
Wang, Bin-cheng
Niu, Guan-nan
Liu, Zhi-hong
Wu, Yong-jian
Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
title Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
title_full Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
title_fullStr Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
title_full_unstemmed Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
title_short Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
title_sort preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis
topic Pharmacology & Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494980/
https://www.ncbi.nlm.nih.gov/pubmed/32893848
http://dx.doi.org/10.1042/BSR20202306
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