An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA

V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell quiescence and inhibits anti-tumor immune responses. VISTA functions by dampening the interaction between myeloid cells and T cells, orthogonal to PD-1 and other checkpoints...

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Detalles Bibliográficos
Autores principales: Mehta, Nishant, Maddineni, Sainiteesh, Kelly, Ryan L., Lee, Robert B., Hunter, Sean A., Silberstein, John L., Parra Sperberg, R. Andres, Miller, Caitlyn L., Rabe, Amanda, Labanieh, Louai, Cochran, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494997/
https://www.ncbi.nlm.nih.gov/pubmed/32938950
http://dx.doi.org/10.1038/s41598-020-71519-4

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