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Observation of angiographic dye leakage in ocular surface squamous neoplasia
PURPOSE: The clinical diagnosis of ocular surface squamous neoplasia is challenging, mostly requiring excisional biopsy. Human tumor angiogenesis is characterized by abnormal vessel architecture and transvascular hyperpermeability. This case report describes features of fluorescein and indocyanine g...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495007/ https://www.ncbi.nlm.nih.gov/pubmed/32984652 http://dx.doi.org/10.1016/j.ajoc.2020.100912 |
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author | Palme, Christoph Wanner, Astrid Romano, Vito Haas, Gertrud Kaye, Stephen Steger, Bernhard |
author_facet | Palme, Christoph Wanner, Astrid Romano, Vito Haas, Gertrud Kaye, Stephen Steger, Bernhard |
author_sort | Palme, Christoph |
collection | PubMed |
description | PURPOSE: The clinical diagnosis of ocular surface squamous neoplasia is challenging, mostly requiring excisional biopsy. Human tumor angiogenesis is characterized by abnormal vessel architecture and transvascular hyperpermeability. This case report describes features of fluorescein and indocyanine green angiography in a case of conjunctival intraepithelial neoplasia. OBSERVATIONS: Color photography, optical coherence tomography, fluorescein and indocyanine green angiography were performed in a patient with suspected conjunctival intraepithelial neoplasia before excisional biopsy and histologic confirmation of clinical diagnosis. Fluorescein dye showed extensive early extravascular dye leakage within the limits of the lesion. Indocyanine green dye displayed corneal terminal vessel bulbs with early leakage after 70 seconds and showed diffuse intralesional dye leakage after 7 minutes. CONCLUSIONS: Increased fluorescein and early indocyanine green dye leakage can be used to confirm active angiogenesis already in early stages of dysplastic ocular surface squamous neoplasia. Late leakage of indocyanine green dye may be due to chronic transvascular hyperpermeability within intrinsic tumor vessels. The leakage behaviour of intravenous dyes has the potential to serve as a diagnostic indicator of active growth in dysplastic ocular surface neoplastic lesions. |
format | Online Article Text |
id | pubmed-7495007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74950072020-09-24 Observation of angiographic dye leakage in ocular surface squamous neoplasia Palme, Christoph Wanner, Astrid Romano, Vito Haas, Gertrud Kaye, Stephen Steger, Bernhard Am J Ophthalmol Case Rep Case Report PURPOSE: The clinical diagnosis of ocular surface squamous neoplasia is challenging, mostly requiring excisional biopsy. Human tumor angiogenesis is characterized by abnormal vessel architecture and transvascular hyperpermeability. This case report describes features of fluorescein and indocyanine green angiography in a case of conjunctival intraepithelial neoplasia. OBSERVATIONS: Color photography, optical coherence tomography, fluorescein and indocyanine green angiography were performed in a patient with suspected conjunctival intraepithelial neoplasia before excisional biopsy and histologic confirmation of clinical diagnosis. Fluorescein dye showed extensive early extravascular dye leakage within the limits of the lesion. Indocyanine green dye displayed corneal terminal vessel bulbs with early leakage after 70 seconds and showed diffuse intralesional dye leakage after 7 minutes. CONCLUSIONS: Increased fluorescein and early indocyanine green dye leakage can be used to confirm active angiogenesis already in early stages of dysplastic ocular surface squamous neoplasia. Late leakage of indocyanine green dye may be due to chronic transvascular hyperpermeability within intrinsic tumor vessels. The leakage behaviour of intravenous dyes has the potential to serve as a diagnostic indicator of active growth in dysplastic ocular surface neoplastic lesions. Elsevier 2020-09-08 /pmc/articles/PMC7495007/ /pubmed/32984652 http://dx.doi.org/10.1016/j.ajoc.2020.100912 Text en © 2020 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Palme, Christoph Wanner, Astrid Romano, Vito Haas, Gertrud Kaye, Stephen Steger, Bernhard Observation of angiographic dye leakage in ocular surface squamous neoplasia |
title | Observation of angiographic dye leakage in ocular surface squamous neoplasia |
title_full | Observation of angiographic dye leakage in ocular surface squamous neoplasia |
title_fullStr | Observation of angiographic dye leakage in ocular surface squamous neoplasia |
title_full_unstemmed | Observation of angiographic dye leakage in ocular surface squamous neoplasia |
title_short | Observation of angiographic dye leakage in ocular surface squamous neoplasia |
title_sort | observation of angiographic dye leakage in ocular surface squamous neoplasia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495007/ https://www.ncbi.nlm.nih.gov/pubmed/32984652 http://dx.doi.org/10.1016/j.ajoc.2020.100912 |
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