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Observation of angiographic dye leakage in ocular surface squamous neoplasia

PURPOSE: The clinical diagnosis of ocular surface squamous neoplasia is challenging, mostly requiring excisional biopsy. Human tumor angiogenesis is characterized by abnormal vessel architecture and transvascular hyperpermeability. This case report describes features of fluorescein and indocyanine g...

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Autores principales: Palme, Christoph, Wanner, Astrid, Romano, Vito, Haas, Gertrud, Kaye, Stephen, Steger, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495007/
https://www.ncbi.nlm.nih.gov/pubmed/32984652
http://dx.doi.org/10.1016/j.ajoc.2020.100912
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author Palme, Christoph
Wanner, Astrid
Romano, Vito
Haas, Gertrud
Kaye, Stephen
Steger, Bernhard
author_facet Palme, Christoph
Wanner, Astrid
Romano, Vito
Haas, Gertrud
Kaye, Stephen
Steger, Bernhard
author_sort Palme, Christoph
collection PubMed
description PURPOSE: The clinical diagnosis of ocular surface squamous neoplasia is challenging, mostly requiring excisional biopsy. Human tumor angiogenesis is characterized by abnormal vessel architecture and transvascular hyperpermeability. This case report describes features of fluorescein and indocyanine green angiography in a case of conjunctival intraepithelial neoplasia. OBSERVATIONS: Color photography, optical coherence tomography, fluorescein and indocyanine green angiography were performed in a patient with suspected conjunctival intraepithelial neoplasia before excisional biopsy and histologic confirmation of clinical diagnosis. Fluorescein dye showed extensive early extravascular dye leakage within the limits of the lesion. Indocyanine green dye displayed corneal terminal vessel bulbs with early leakage after 70 seconds and showed diffuse intralesional dye leakage after 7 minutes. CONCLUSIONS: Increased fluorescein and early indocyanine green dye leakage can be used to confirm active angiogenesis already in early stages of dysplastic ocular surface squamous neoplasia. Late leakage of indocyanine green dye may be due to chronic transvascular hyperpermeability within intrinsic tumor vessels. The leakage behaviour of intravenous dyes has the potential to serve as a diagnostic indicator of active growth in dysplastic ocular surface neoplastic lesions.
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spelling pubmed-74950072020-09-24 Observation of angiographic dye leakage in ocular surface squamous neoplasia Palme, Christoph Wanner, Astrid Romano, Vito Haas, Gertrud Kaye, Stephen Steger, Bernhard Am J Ophthalmol Case Rep Case Report PURPOSE: The clinical diagnosis of ocular surface squamous neoplasia is challenging, mostly requiring excisional biopsy. Human tumor angiogenesis is characterized by abnormal vessel architecture and transvascular hyperpermeability. This case report describes features of fluorescein and indocyanine green angiography in a case of conjunctival intraepithelial neoplasia. OBSERVATIONS: Color photography, optical coherence tomography, fluorescein and indocyanine green angiography were performed in a patient with suspected conjunctival intraepithelial neoplasia before excisional biopsy and histologic confirmation of clinical diagnosis. Fluorescein dye showed extensive early extravascular dye leakage within the limits of the lesion. Indocyanine green dye displayed corneal terminal vessel bulbs with early leakage after 70 seconds and showed diffuse intralesional dye leakage after 7 minutes. CONCLUSIONS: Increased fluorescein and early indocyanine green dye leakage can be used to confirm active angiogenesis already in early stages of dysplastic ocular surface squamous neoplasia. Late leakage of indocyanine green dye may be due to chronic transvascular hyperpermeability within intrinsic tumor vessels. The leakage behaviour of intravenous dyes has the potential to serve as a diagnostic indicator of active growth in dysplastic ocular surface neoplastic lesions. Elsevier 2020-09-08 /pmc/articles/PMC7495007/ /pubmed/32984652 http://dx.doi.org/10.1016/j.ajoc.2020.100912 Text en © 2020 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Palme, Christoph
Wanner, Astrid
Romano, Vito
Haas, Gertrud
Kaye, Stephen
Steger, Bernhard
Observation of angiographic dye leakage in ocular surface squamous neoplasia
title Observation of angiographic dye leakage in ocular surface squamous neoplasia
title_full Observation of angiographic dye leakage in ocular surface squamous neoplasia
title_fullStr Observation of angiographic dye leakage in ocular surface squamous neoplasia
title_full_unstemmed Observation of angiographic dye leakage in ocular surface squamous neoplasia
title_short Observation of angiographic dye leakage in ocular surface squamous neoplasia
title_sort observation of angiographic dye leakage in ocular surface squamous neoplasia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495007/
https://www.ncbi.nlm.nih.gov/pubmed/32984652
http://dx.doi.org/10.1016/j.ajoc.2020.100912
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