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Papillitis with retinal venous congestion and intraocular inflammation

PURPOSE: To describe a case of pronounced papillitis with diminished venous outflow and vitreous inflammation in a 50-year-old man who was later found to have clinical and serological manifestations of dermatomyositis. OBSERVATIONS: A 50-year-old man presented with papillitis associated with venous...

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Autores principales: Wu, Connie M., Dunn, James P., Sergott, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495011/
https://www.ncbi.nlm.nih.gov/pubmed/32984653
http://dx.doi.org/10.1016/j.ajoc.2020.100913
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author Wu, Connie M.
Dunn, James P.
Sergott, Robert C.
author_facet Wu, Connie M.
Dunn, James P.
Sergott, Robert C.
author_sort Wu, Connie M.
collection PubMed
description PURPOSE: To describe a case of pronounced papillitis with diminished venous outflow and vitreous inflammation in a 50-year-old man who was later found to have clinical and serological manifestations of dermatomyositis. OBSERVATIONS: A 50-year-old man presented with papillitis associated with venous congestion and intraocular inflammation. He was normotensive, not on medications, and without known heritable hypercoagulable or inflammatory disease. Review of systems revealed axial and proximal muscle pain involving the lower back, hip, and thigh, and he developed a transient rash of the scalp. His evaluation including infectious, hypercoagulable, and inflammatory etiologies was negative except for a significantly elevated Mi-2 antibody titer. Treatment with intravenous and oral steroids improved the papillitis, visual acuity and visual field deficit. CONCLUSIONS: Significant papillitis and retinal venous stasis with intraocular inflammation may be associated with dermatomyositis. IMPORTANCE: Rapidly progressive optic disc edema with associated inflammation and venous stasis requires a broad work up for infectious, hypercoagulable, and autoimmune etiologies for targeted therapy and visual preservation. To the best of our knowledge, this may be the first reported clinical presentation of dermatomyositis manifesting initially with papillitis and retinal venous congestion, based upon elevated Mi-2 antibodies and additional clinical features.
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spelling pubmed-74950112020-09-24 Papillitis with retinal venous congestion and intraocular inflammation Wu, Connie M. Dunn, James P. Sergott, Robert C. Am J Ophthalmol Case Rep Case Report PURPOSE: To describe a case of pronounced papillitis with diminished venous outflow and vitreous inflammation in a 50-year-old man who was later found to have clinical and serological manifestations of dermatomyositis. OBSERVATIONS: A 50-year-old man presented with papillitis associated with venous congestion and intraocular inflammation. He was normotensive, not on medications, and without known heritable hypercoagulable or inflammatory disease. Review of systems revealed axial and proximal muscle pain involving the lower back, hip, and thigh, and he developed a transient rash of the scalp. His evaluation including infectious, hypercoagulable, and inflammatory etiologies was negative except for a significantly elevated Mi-2 antibody titer. Treatment with intravenous and oral steroids improved the papillitis, visual acuity and visual field deficit. CONCLUSIONS: Significant papillitis and retinal venous stasis with intraocular inflammation may be associated with dermatomyositis. IMPORTANCE: Rapidly progressive optic disc edema with associated inflammation and venous stasis requires a broad work up for infectious, hypercoagulable, and autoimmune etiologies for targeted therapy and visual preservation. To the best of our knowledge, this may be the first reported clinical presentation of dermatomyositis manifesting initially with papillitis and retinal venous congestion, based upon elevated Mi-2 antibodies and additional clinical features. Elsevier 2020-09-10 /pmc/articles/PMC7495011/ /pubmed/32984653 http://dx.doi.org/10.1016/j.ajoc.2020.100913 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wu, Connie M.
Dunn, James P.
Sergott, Robert C.
Papillitis with retinal venous congestion and intraocular inflammation
title Papillitis with retinal venous congestion and intraocular inflammation
title_full Papillitis with retinal venous congestion and intraocular inflammation
title_fullStr Papillitis with retinal venous congestion and intraocular inflammation
title_full_unstemmed Papillitis with retinal venous congestion and intraocular inflammation
title_short Papillitis with retinal venous congestion and intraocular inflammation
title_sort papillitis with retinal venous congestion and intraocular inflammation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495011/
https://www.ncbi.nlm.nih.gov/pubmed/32984653
http://dx.doi.org/10.1016/j.ajoc.2020.100913
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