Cargando…
Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease
Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular pathologies. As seen in other hemolytic diseases,...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495019/ https://www.ncbi.nlm.nih.gov/pubmed/33013455 http://dx.doi.org/10.3389/fphys.2020.01063 |
_version_ | 1783582849325072384 |
---|---|
author | Lapping-Carr, Gabrielle Gemel, Joanna Mao, Yifan Beyer, Eric C. |
author_facet | Lapping-Carr, Gabrielle Gemel, Joanna Mao, Yifan Beyer, Eric C. |
author_sort | Lapping-Carr, Gabrielle |
collection | PubMed |
description | Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular pathologies. As seen in other hemolytic diseases, the plasma of sickle cell patients contains EVs of different sizes and cellular sources. The medium-sized vesicles (microparticles) primarily derive from mature red blood cells and platelets; some of these EVs have procoagulant properties, while others stimulate inflammation or endothelial adhesiveness. Most of the small EVs (including exosomes) derive from erythrocytes and erythrocyte precursors, but some also originate from platelets, white blood cells, and endothelial cells. These small EVs may alter the behavior of target cells by delivering cargo including proteins and nucleic acids. Studies in model systems implicate small EVs in promoting vaso-occlusion and disruption of endothelial integrity. Thus, both medium and small EVs may contribute to the increased endothelial damage in sickle cell disease. Development of a detailed understanding of the composition and roles of circulating EVs represents a promising approach toward novel predictive diagnostics and therapeutic approaches in sickle cell disease. |
format | Online Article Text |
id | pubmed-7495019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74950192020-10-02 Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease Lapping-Carr, Gabrielle Gemel, Joanna Mao, Yifan Beyer, Eric C. Front Physiol Physiology Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular pathologies. As seen in other hemolytic diseases, the plasma of sickle cell patients contains EVs of different sizes and cellular sources. The medium-sized vesicles (microparticles) primarily derive from mature red blood cells and platelets; some of these EVs have procoagulant properties, while others stimulate inflammation or endothelial adhesiveness. Most of the small EVs (including exosomes) derive from erythrocytes and erythrocyte precursors, but some also originate from platelets, white blood cells, and endothelial cells. These small EVs may alter the behavior of target cells by delivering cargo including proteins and nucleic acids. Studies in model systems implicate small EVs in promoting vaso-occlusion and disruption of endothelial integrity. Thus, both medium and small EVs may contribute to the increased endothelial damage in sickle cell disease. Development of a detailed understanding of the composition and roles of circulating EVs represents a promising approach toward novel predictive diagnostics and therapeutic approaches in sickle cell disease. Frontiers Media S.A. 2020-09-03 /pmc/articles/PMC7495019/ /pubmed/33013455 http://dx.doi.org/10.3389/fphys.2020.01063 Text en Copyright © 2020 Lapping-Carr, Gemel, Mao and Beyer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Lapping-Carr, Gabrielle Gemel, Joanna Mao, Yifan Beyer, Eric C. Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
title | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
title_full | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
title_fullStr | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
title_full_unstemmed | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
title_short | Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease |
title_sort | circulating extracellular vesicles and endothelial damage in sickle cell disease |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495019/ https://www.ncbi.nlm.nih.gov/pubmed/33013455 http://dx.doi.org/10.3389/fphys.2020.01063 |
work_keys_str_mv | AT lappingcarrgabrielle circulatingextracellularvesiclesandendothelialdamageinsicklecelldisease AT gemeljoanna circulatingextracellularvesiclesandendothelialdamageinsicklecelldisease AT maoyifan circulatingextracellularvesiclesandendothelialdamageinsicklecelldisease AT beyerericc circulatingextracellularvesiclesandendothelialdamageinsicklecelldisease |