Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

BACKGROUND: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. In a phase IIb clinical trial in patients with nonalcoholic steatohepatiti...

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Detalles Bibliográficos
Autores principales: Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Delacruz-Villar, Laura, Bilbao, Jon, Pagano, Martina, Mosca, Laura, Bizkarguenaga, Maider, Serrano-Macia, Marina, Azkargorta, Mikel, Iruarrizaga-Lejarreta, Marta, Sot, Jesús, Tsvirkun, Darya, van Liempd, Sebastiaan Martijn, Goni, Felix M, Alonso, Cristina, Martínez-Chantar, María Luz, Elortza, Felix, Hayardeny, Liat, Lu, Shelly C, Mato, José M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495035/
https://www.ncbi.nlm.nih.gov/pubmed/32982112
http://dx.doi.org/10.3748/wjg.v26.i34.5101

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