Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells

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Post-translational modification by SUMO is a key regulator of cell identity. In mouse embryonic fibroblasts (MEFs), SUMO impedes reprogramming to pluripotency, while in embryonic stem cells (ESCs), it represses the emergence of totipotent-like cells, suggesting that SUMO targets distinct substrates...

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Detalles Bibliográficos
Autores principales: Theurillat, Ilan, Hendriks, Ivo A., Cossec, Jack-Christophe, Andrieux, Alexandra, Nielsen, Michael L., Dejean, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495044/
https://www.ncbi.nlm.nih.gov/pubmed/32937131
http://dx.doi.org/10.1016/j.celrep.2020.108146
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