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Men and COVID-19: A Pathophysiologic Review

Coronaviruses are single-stranded ribonucleic acid viruses that can cause illnesses in humans ranging from the common cold to severe respiratory disease and even death.In March 2020, the World Health Organization declared the 2019 novel coronavirus disease (COVID-19) caused by the severe acute respi...

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Detalles Bibliográficos
Autores principales: Lipsky, Martin S., Hung, Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495118/
https://www.ncbi.nlm.nih.gov/pubmed/32936693
http://dx.doi.org/10.1177/1557988320954021
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author Lipsky, Martin S.
Hung, Man
author_facet Lipsky, Martin S.
Hung, Man
author_sort Lipsky, Martin S.
collection PubMed
description Coronaviruses are single-stranded ribonucleic acid viruses that can cause illnesses in humans ranging from the common cold to severe respiratory disease and even death.In March 2020, the World Health Organization declared the 2019 novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the first pandemic. Compared to women, most countries with available data report that men with COVID-19 have greater disease severity and higher mortality. Lab and animal data indicate that men respond differently to the SARS-CoV-2 infection, offering possible explanations for the epidemiologic observations. The plausible theories underlying these observations include sex-related differences in angiotensin-converting enzyme 2 receptors, immune function, hormones, habits, and coinfection rates.In this review we examine these factors and explore the rationale as to how each may impact COVID-19. Understanding why men are more likely to experience severe disease can help in developing effective treatments, public health policies, and targeted strategies such as early recognition and aggressive testing in subgroups.
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spelling pubmed-74951182020-09-17 Men and COVID-19: A Pathophysiologic Review Lipsky, Martin S. Hung, Man Am J Mens Health Review Coronaviruses are single-stranded ribonucleic acid viruses that can cause illnesses in humans ranging from the common cold to severe respiratory disease and even death.In March 2020, the World Health Organization declared the 2019 novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the first pandemic. Compared to women, most countries with available data report that men with COVID-19 have greater disease severity and higher mortality. Lab and animal data indicate that men respond differently to the SARS-CoV-2 infection, offering possible explanations for the epidemiologic observations. The plausible theories underlying these observations include sex-related differences in angiotensin-converting enzyme 2 receptors, immune function, hormones, habits, and coinfection rates.In this review we examine these factors and explore the rationale as to how each may impact COVID-19. Understanding why men are more likely to experience severe disease can help in developing effective treatments, public health policies, and targeted strategies such as early recognition and aggressive testing in subgroups. SAGE Publications 2020-09-16 /pmc/articles/PMC7495118/ /pubmed/32936693 http://dx.doi.org/10.1177/1557988320954021 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Lipsky, Martin S.
Hung, Man
Men and COVID-19: A Pathophysiologic Review
title Men and COVID-19: A Pathophysiologic Review
title_full Men and COVID-19: A Pathophysiologic Review
title_fullStr Men and COVID-19: A Pathophysiologic Review
title_full_unstemmed Men and COVID-19: A Pathophysiologic Review
title_short Men and COVID-19: A Pathophysiologic Review
title_sort men and covid-19: a pathophysiologic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495118/
https://www.ncbi.nlm.nih.gov/pubmed/32936693
http://dx.doi.org/10.1177/1557988320954021
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