Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach

Adeno-associated viruses (AAV) are composed of nonenveloped, icosahedral protein shells that can be adapted to package and deliver recombinant therapeutic DNA. Approaches to engineer recombinant capsids for gene therapy applications have focused on rational design or library-based approaches that ca...

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Detalles Bibliográficos
Autores principales: Havlik, L. Patrick, Simon, Katherine E., Smith, J. Kennon, Klinc, Kelli A., Tse, Longping V., Oh, Daniel K., Fanous, Marco M., Meganck, Rita M., Mietzsch, Mario, Kleinschmidt, Jürgen, Agbandje-McKenna, Mavis, Asokan, Aravind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Gene Delivery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495376/
https://www.ncbi.nlm.nih.gov/pubmed/32669336
http://dx.doi.org/10.1128/JVI.00976-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495376/
https://www.ncbi.nlm.nih.gov/pubmed/32669336
http://dx.doi.org/10.1128/JVI.00976-20

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