Immune Escape Adaptive Mutations in the H7N9 Avian Influenza Hemagglutinin Protein Increase Virus Replication Fitness and Decrease Pandemic Potential

H7N9 avian influenza viruses (AIVs) continue to evolve and remain a huge threat to human health and the poultry industry. Previously, serially passaging the H7N9 A/Anhui/1/2013 virus in the presence of homologous ferret antiserum resulted in immune escape viruses containing amino acid substitutions...

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Detalles Bibliográficos
Autores principales: Chang, Pengxiang, Sealy, Joshua E., Sadeyen, Jean-Remy, Bhat, Sushant, Lukosaityte, Deimante, Sun, Yipeng, Iqbal, Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495387/
https://www.ncbi.nlm.nih.gov/pubmed/32699084
http://dx.doi.org/10.1128/JVI.00216-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495387/
https://www.ncbi.nlm.nih.gov/pubmed/32699084
http://dx.doi.org/10.1128/JVI.00216-20

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