Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions paradoxically stimulate the translation of ATF4 mRNA through a regulatory 5′ leader sequence with multiple upstream Op...

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Detalles Bibliográficos
Autores principales: Vasudevan, Deepika, Neuman, Sarah D., Yang, Amy, Lough, Lea, Brown, Brian, Bashirullah, Arash, Cardozo, Timothy, Ryoo, Hyung Don
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495428/
https://www.ncbi.nlm.nih.gov/pubmed/32938929
http://dx.doi.org/10.1038/s41467-020-18453-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495428/
https://www.ncbi.nlm.nih.gov/pubmed/32938929
http://dx.doi.org/10.1038/s41467-020-18453-1

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