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Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer
Few studies have evaluated the usefulness of video-assisted thoracoscopic surgery (VATS) for advanced-stage lung cancer. We aimed to evaluate the feasibility of VATS for treating clinical N2 (cN2) lung cancer. A retrospective cohort analysis was performed with data from 268 patients who underwent lo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495470/ https://www.ncbi.nlm.nih.gov/pubmed/32939008 http://dx.doi.org/10.1038/s41598-020-72272-4 |
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author | Yun, Jae Kwang Lee, Geun Dong Choi, Sehoon Kim, Hyeong Ryul Kim, Yong-Hee Park, Seung-Il Kim, Dong Kwan |
author_facet | Yun, Jae Kwang Lee, Geun Dong Choi, Sehoon Kim, Hyeong Ryul Kim, Yong-Hee Park, Seung-Il Kim, Dong Kwan |
author_sort | Yun, Jae Kwang |
collection | PubMed |
description | Few studies have evaluated the usefulness of video-assisted thoracoscopic surgery (VATS) for advanced-stage lung cancer. We aimed to evaluate the feasibility of VATS for treating clinical N2 (cN2) lung cancer. A retrospective cohort analysis was performed with data from 268 patients who underwent lobectomy for cN2 disease from 2007 to 2016. Using propensity score-based inverse probability of treatment weighting (IPTW), perioperative and long-term survival outcomes were compared. We performed VATS and open thoracotomy on 121 and 147 patients, respectively. Overall, VATS was preferred for patients with peripherally located tumors (p < 0.001). After IPTW-adjustment, all preoperative information became similar between the groups. Compared to thoracotomy, VATS was associated with shorter hospitalization (7.7 days vs. 9.1 days, p = 0.028), despite equivalent complete resection rates (92.6% vs. 90.5%, p = 0.488) and dissected lymph nodes (mean, 31.9 vs. 29.4, p = 0.100). On IPTW-adjusted analysis, overall survival (50.5% vs. 48.4%, p = 0.127) and recurrence-free survival (60.5% vs 44.6%, p = 0.069) at 5 years were also similar between the groups. Among selected patients with resectable cN2 disease and peripherally located tumors, VATS is feasible, associated with shorter hospitalization and comparable perioperative and long-term survival outcomes, compared with open thoracotomy. |
format | Online Article Text |
id | pubmed-7495470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74954702020-09-18 Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer Yun, Jae Kwang Lee, Geun Dong Choi, Sehoon Kim, Hyeong Ryul Kim, Yong-Hee Park, Seung-Il Kim, Dong Kwan Sci Rep Article Few studies have evaluated the usefulness of video-assisted thoracoscopic surgery (VATS) for advanced-stage lung cancer. We aimed to evaluate the feasibility of VATS for treating clinical N2 (cN2) lung cancer. A retrospective cohort analysis was performed with data from 268 patients who underwent lobectomy for cN2 disease from 2007 to 2016. Using propensity score-based inverse probability of treatment weighting (IPTW), perioperative and long-term survival outcomes were compared. We performed VATS and open thoracotomy on 121 and 147 patients, respectively. Overall, VATS was preferred for patients with peripherally located tumors (p < 0.001). After IPTW-adjustment, all preoperative information became similar between the groups. Compared to thoracotomy, VATS was associated with shorter hospitalization (7.7 days vs. 9.1 days, p = 0.028), despite equivalent complete resection rates (92.6% vs. 90.5%, p = 0.488) and dissected lymph nodes (mean, 31.9 vs. 29.4, p = 0.100). On IPTW-adjusted analysis, overall survival (50.5% vs. 48.4%, p = 0.127) and recurrence-free survival (60.5% vs 44.6%, p = 0.069) at 5 years were also similar between the groups. Among selected patients with resectable cN2 disease and peripherally located tumors, VATS is feasible, associated with shorter hospitalization and comparable perioperative and long-term survival outcomes, compared with open thoracotomy. Nature Publishing Group UK 2020-09-16 /pmc/articles/PMC7495470/ /pubmed/32939008 http://dx.doi.org/10.1038/s41598-020-72272-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yun, Jae Kwang Lee, Geun Dong Choi, Sehoon Kim, Hyeong Ryul Kim, Yong-Hee Park, Seung-Il Kim, Dong Kwan Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer |
title | Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer |
title_full | Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer |
title_fullStr | Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer |
title_full_unstemmed | Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer |
title_short | Video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical N2 non-small cell lung cancer |
title_sort | video-assisted thoracoscopic lobectomy is feasible for selected patients with clinical n2 non-small cell lung cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495470/ https://www.ncbi.nlm.nih.gov/pubmed/32939008 http://dx.doi.org/10.1038/s41598-020-72272-4 |
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