Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

SETD2 catalyzes methylation at lysine 36 of histone H3 and it has many disease connections. We investigated the substrate sequence specificity of SETD2 and identified nine additional peptide and one protein (FBN1) substrates. Our data showed that SETD2 strongly prefers amino acids different from tho...

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Detalles Bibliográficos
Autores principales: Schuhmacher, Maren Kirstin, Beldar, Serap, Khella, Mina S., Bröhm, Alexander, Ludwig, Jan, Tempel, Wolfram, Weirich, Sara, Min, Jinrong, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495481/
https://www.ncbi.nlm.nih.gov/pubmed/32939018
http://dx.doi.org/10.1038/s42003-020-01223-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495481/
https://www.ncbi.nlm.nih.gov/pubmed/32939018
http://dx.doi.org/10.1038/s42003-020-01223-6

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