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The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer

BACKGROUND: Apparent diffusion coefficient (ADC) values achieve promising results in treatment response prediction in patients with several types of cancers. PURPOSE: To determine whether ADC values predict neoadjuvant chemoradiation treatment (nCRT) response in patients with locally advanced rectal...

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Autores principales: Jiménez de los Santos, Mayra Evelia, Reyes-Pérez, Juan Armando, Sandoval-Nava, Rosa Martha, Villalobos-Juárez, José Luis, Villaseñor-Navarro, Yolanda, Vela-Sarmiento, Itzel, Sollozo-Dupont, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495679/
https://www.ncbi.nlm.nih.gov/pubmed/32974055
http://dx.doi.org/10.1177/2058460120957295
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author Jiménez de los Santos, Mayra Evelia
Reyes-Pérez, Juan Armando
Sandoval-Nava, Rosa Martha
Villalobos-Juárez, José Luis
Villaseñor-Navarro, Yolanda
Vela-Sarmiento, Itzel
Sollozo-Dupont, Isabel
author_facet Jiménez de los Santos, Mayra Evelia
Reyes-Pérez, Juan Armando
Sandoval-Nava, Rosa Martha
Villalobos-Juárez, José Luis
Villaseñor-Navarro, Yolanda
Vela-Sarmiento, Itzel
Sollozo-Dupont, Isabel
author_sort Jiménez de los Santos, Mayra Evelia
collection PubMed
description BACKGROUND: Apparent diffusion coefficient (ADC) values achieve promising results in treatment response prediction in patients with several types of cancers. PURPOSE: To determine whether ADC values predict neoadjuvant chemoradiation treatment (nCRT) response in patients with locally advanced rectal cancer (LARC). MATERIAL AND METHODS: Forty-four patients with LARC who underwent magnetic resonance imaging scans before and after nCRT followed by delayed surgery were enrolled retrospectively. The sample was distributed as follows: responders (R), n = 8; and non-responders (Non-R), n = 36. Three markers of treatment response were considered: post-nCRT measures; ΔADC; and Δ%ADC. Statistical analysis included a Wilcoxon test, a Mann–Whitney U test, and a receiver operating characteristic (ROC) analysis in order to evaluate the diagnostic accuracy for each ADC value marker to differentiate between R and Non-R. RESULTS: Both minimum and mean ADC values were significantly higher after nCRT in the R group, while non-significant differences between basal and control ADC values were found in the non-R group. In addition, ΔADC and Δ%ADC exhibited increased values after nCRT in R when compared with non-R. ROC analysis revealed the following diagnostic performance parameters: post-nCRT: ADC(min) = 1.05 × 10(−3) mm(2)/s (sensitivity 61.1% and specificity 66.7%), ADC(mean) = 1.50 × 10(−3) mm(2)/s (sensitivity 72.2% and specificity 83.3%), ΔADC: ADC(min) = 0.35 (sensitivity 66.7% and specificity 83.3%), ADC(mean) = 0.50 (sensitivity 72% and specificity 83%); and Δ%ADC: ADC(min) = 44% (sensitivity 66.7% and specificity 83.3%) and ADC(mean) = 60% (sensitivity 83% and specificity 99%). CONCLUSION: Our findings suggest that post-treatment rectal tumor ADC values, as well changes between pre- and post-treatment values, may be biomarkers for predicting treatment response in patients with LARC who underwent nCRT.
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spelling pubmed-74956792020-09-23 The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer Jiménez de los Santos, Mayra Evelia Reyes-Pérez, Juan Armando Sandoval-Nava, Rosa Martha Villalobos-Juárez, José Luis Villaseñor-Navarro, Yolanda Vela-Sarmiento, Itzel Sollozo-Dupont, Isabel Acta Radiol Open Original Article BACKGROUND: Apparent diffusion coefficient (ADC) values achieve promising results in treatment response prediction in patients with several types of cancers. PURPOSE: To determine whether ADC values predict neoadjuvant chemoradiation treatment (nCRT) response in patients with locally advanced rectal cancer (LARC). MATERIAL AND METHODS: Forty-four patients with LARC who underwent magnetic resonance imaging scans before and after nCRT followed by delayed surgery were enrolled retrospectively. The sample was distributed as follows: responders (R), n = 8; and non-responders (Non-R), n = 36. Three markers of treatment response were considered: post-nCRT measures; ΔADC; and Δ%ADC. Statistical analysis included a Wilcoxon test, a Mann–Whitney U test, and a receiver operating characteristic (ROC) analysis in order to evaluate the diagnostic accuracy for each ADC value marker to differentiate between R and Non-R. RESULTS: Both minimum and mean ADC values were significantly higher after nCRT in the R group, while non-significant differences between basal and control ADC values were found in the non-R group. In addition, ΔADC and Δ%ADC exhibited increased values after nCRT in R when compared with non-R. ROC analysis revealed the following diagnostic performance parameters: post-nCRT: ADC(min) = 1.05 × 10(−3) mm(2)/s (sensitivity 61.1% and specificity 66.7%), ADC(mean) = 1.50 × 10(−3) mm(2)/s (sensitivity 72.2% and specificity 83.3%), ΔADC: ADC(min) = 0.35 (sensitivity 66.7% and specificity 83.3%), ADC(mean) = 0.50 (sensitivity 72% and specificity 83%); and Δ%ADC: ADC(min) = 44% (sensitivity 66.7% and specificity 83.3%) and ADC(mean) = 60% (sensitivity 83% and specificity 99%). CONCLUSION: Our findings suggest that post-treatment rectal tumor ADC values, as well changes between pre- and post-treatment values, may be biomarkers for predicting treatment response in patients with LARC who underwent nCRT. SAGE Publications 2020-09-15 /pmc/articles/PMC7495679/ /pubmed/32974055 http://dx.doi.org/10.1177/2058460120957295 Text en © The Foundation Acta Radiologica 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Jiménez de los Santos, Mayra Evelia
Reyes-Pérez, Juan Armando
Sandoval-Nava, Rosa Martha
Villalobos-Juárez, José Luis
Villaseñor-Navarro, Yolanda
Vela-Sarmiento, Itzel
Sollozo-Dupont, Isabel
The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
title The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
title_full The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
title_fullStr The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
title_full_unstemmed The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
title_short The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
title_sort apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495679/
https://www.ncbi.nlm.nih.gov/pubmed/32974055
http://dx.doi.org/10.1177/2058460120957295
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