Impact of Mutations on the Conformational Transition from α-Helix to β-Sheet Structures in Arctic-Type Aβ(40): Insights from Molecular Dynamics Simulations

[Image: see text] The amyloid-β (Aβ) protein aggregation into toxic oligomers and fibrils has been recognized as a key player in the pathogenesis of Alzheimer’s disease. Recent experiments reported that a double alanine mutation (L17A/F19A) in the central hydrophobic core (CHC) region of [G22]Aβ(40)...

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Detalles Bibliográficos
Autores principales: Saini, Rajneet Kaur, Shuaib, Suniba, Goyal, Deepti, Goyal, Bhupesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495726/
https://www.ncbi.nlm.nih.gov/pubmed/32954172
http://dx.doi.org/10.1021/acsomega.0c02983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495726/
https://www.ncbi.nlm.nih.gov/pubmed/32954172
http://dx.doi.org/10.1021/acsomega.0c02983

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