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Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis
BACKGROUND: A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies investigating the association between types of ACEs and persistent pain have yielde...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495859/ https://www.ncbi.nlm.nih.gov/pubmed/32943108 http://dx.doi.org/10.1186/s13643-020-01474-8 |
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author | Bussières, André Hartvigsen, Jan Ferreira, Manuela L. Ferreira, Paulo H. Hancock, Mark J. Stone, Laura S. Wideman, Timothy H. Boruff, Jill Elklit, Ask |
author_facet | Bussières, André Hartvigsen, Jan Ferreira, Manuela L. Ferreira, Paulo H. Hancock, Mark J. Stone, Laura S. Wideman, Timothy H. Boruff, Jill Elklit, Ask |
author_sort | Bussières, André |
collection | PubMed |
description | BACKGROUND: A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies investigating the association between types of ACEs and persistent pain have yielded inconsistent findings in the strength and direction of associations. The purpose of this review is to appraise and summarize evidence on the relationship between ACEs and persistent pain and disability outcomes in adulthood. The specific aims are (1) to determine whether there is a relationship between exposure to ACE and persistent pain and disability in adults and (2) to determine whether unique and cumulative ACEs exposures (number and type) increase the risk of developing persistent pain and disability in adulthood. METHOD: A systematic review and meta-analysis of observational studies will be conducted. Our eligibility criteria are defined following a PECOS approach: population, adults with persistent (≥ 3 months) musculoskeletal and somatoform painful disorders exposed to single or cumulative direct ACEs alone (i.e., physical, sexual, emotional abuse or neglect) or in combination to indirect types of ACE (e.g., parental death, exposure to domestic violence) in the first 18 years of life; comparators, unexposed individuals; outcomes, measurements for persistent pain (≥ 3 months) and disability using discrete and/or continuous measures; and settings, general population, primary care. A comprehensive search of MEDLINE (Ovid) and nine other pertinent databases was conducted from inception to 29 August 2019 using a combination of key words and MeSh terms (the search will be updated prior to conducting the analyses). Pairs of reviewers will independently screen records and full text articles, and a third reviewer will be consulted in cases of disagreement. Data will be extracted using Endnote and Covidence and a meta-analysis will be conducted using Review Manager (RevMan) Version 5.3. The Scottish Intercollegiate Guidelines Network (SIGN) and the Joanna Briggs Institute (JBI) checklists will be used to assess the quality of the included studies. If heterogeneity is high, the findings will be presented in narrative form. DISCUSSION: The present review will help consolidate knowledge on persistent pain and disability by evaluating whether frequency and type of adverse childhood experiences produces the most harm. Findings may help inform practitioners and policy-makers who endeavor to prevent and/or mitigate the consequences of ACEs and promote healthy development and well-being of children, youth, and families. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020150230 |
format | Online Article Text |
id | pubmed-7495859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74958592020-09-23 Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis Bussières, André Hartvigsen, Jan Ferreira, Manuela L. Ferreira, Paulo H. Hancock, Mark J. Stone, Laura S. Wideman, Timothy H. Boruff, Jill Elklit, Ask Syst Rev Protocol BACKGROUND: A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies investigating the association between types of ACEs and persistent pain have yielded inconsistent findings in the strength and direction of associations. The purpose of this review is to appraise and summarize evidence on the relationship between ACEs and persistent pain and disability outcomes in adulthood. The specific aims are (1) to determine whether there is a relationship between exposure to ACE and persistent pain and disability in adults and (2) to determine whether unique and cumulative ACEs exposures (number and type) increase the risk of developing persistent pain and disability in adulthood. METHOD: A systematic review and meta-analysis of observational studies will be conducted. Our eligibility criteria are defined following a PECOS approach: population, adults with persistent (≥ 3 months) musculoskeletal and somatoform painful disorders exposed to single or cumulative direct ACEs alone (i.e., physical, sexual, emotional abuse or neglect) or in combination to indirect types of ACE (e.g., parental death, exposure to domestic violence) in the first 18 years of life; comparators, unexposed individuals; outcomes, measurements for persistent pain (≥ 3 months) and disability using discrete and/or continuous measures; and settings, general population, primary care. A comprehensive search of MEDLINE (Ovid) and nine other pertinent databases was conducted from inception to 29 August 2019 using a combination of key words and MeSh terms (the search will be updated prior to conducting the analyses). Pairs of reviewers will independently screen records and full text articles, and a third reviewer will be consulted in cases of disagreement. Data will be extracted using Endnote and Covidence and a meta-analysis will be conducted using Review Manager (RevMan) Version 5.3. The Scottish Intercollegiate Guidelines Network (SIGN) and the Joanna Briggs Institute (JBI) checklists will be used to assess the quality of the included studies. If heterogeneity is high, the findings will be presented in narrative form. DISCUSSION: The present review will help consolidate knowledge on persistent pain and disability by evaluating whether frequency and type of adverse childhood experiences produces the most harm. Findings may help inform practitioners and policy-makers who endeavor to prevent and/or mitigate the consequences of ACEs and promote healthy development and well-being of children, youth, and families. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020150230 BioMed Central 2020-09-17 /pmc/articles/PMC7495859/ /pubmed/32943108 http://dx.doi.org/10.1186/s13643-020-01474-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Protocol Bussières, André Hartvigsen, Jan Ferreira, Manuela L. Ferreira, Paulo H. Hancock, Mark J. Stone, Laura S. Wideman, Timothy H. Boruff, Jill Elklit, Ask Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
title | Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
title_full | Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
title_fullStr | Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
title_full_unstemmed | Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
title_short | Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
title_sort | adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495859/ https://www.ncbi.nlm.nih.gov/pubmed/32943108 http://dx.doi.org/10.1186/s13643-020-01474-8 |
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