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Calcium oxalate crystal deposition in the kidney: identification, causes and consequences

Calcium oxalate (CaOx) crystal deposition within the tubules is often a perplexing finding on renal biopsy of both native and transplanted kidneys. Understanding the underlying causes may help diagnosis and future management. The most frequent cause of CaOx crystal deposition within the kidney is hy...

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Autores principales: Geraghty, R., Wood, K., Sayer, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496019/
https://www.ncbi.nlm.nih.gov/pubmed/32719990
http://dx.doi.org/10.1007/s00240-020-01202-w
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author Geraghty, R.
Wood, K.
Sayer, J. A.
author_facet Geraghty, R.
Wood, K.
Sayer, J. A.
author_sort Geraghty, R.
collection PubMed
description Calcium oxalate (CaOx) crystal deposition within the tubules is often a perplexing finding on renal biopsy of both native and transplanted kidneys. Understanding the underlying causes may help diagnosis and future management. The most frequent cause of CaOx crystal deposition within the kidney is hyperoxaluria. When this is seen in native kidney biopsy, primary hyperoxaluria must be considered and investigated further with biochemical and genetic tests. Secondary hyperoxaluria, for example due to enteric hyperoxaluria following bariatric surgery, ingested ethylene glycol or vitamin C overdose may also cause CaOx deposition in native kidneys. CaOx deposition is a frequent finding in renal transplant biopsy, often as a consequence of acute tubular necrosis and is associated with poorer long-term graft outcomes. CaOx crystal deposition in the renal transplant may also be secondary to any of the causes associated with this phenotype in the native kidney. The pathophysiology underlying CaOx deposition is complex but this histological phenotype may indicate serious underlying pathology and should always warrant further investigation.
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spelling pubmed-74960192020-09-29 Calcium oxalate crystal deposition in the kidney: identification, causes and consequences Geraghty, R. Wood, K. Sayer, J. A. Urolithiasis Invited Review Calcium oxalate (CaOx) crystal deposition within the tubules is often a perplexing finding on renal biopsy of both native and transplanted kidneys. Understanding the underlying causes may help diagnosis and future management. The most frequent cause of CaOx crystal deposition within the kidney is hyperoxaluria. When this is seen in native kidney biopsy, primary hyperoxaluria must be considered and investigated further with biochemical and genetic tests. Secondary hyperoxaluria, for example due to enteric hyperoxaluria following bariatric surgery, ingested ethylene glycol or vitamin C overdose may also cause CaOx deposition in native kidneys. CaOx deposition is a frequent finding in renal transplant biopsy, often as a consequence of acute tubular necrosis and is associated with poorer long-term graft outcomes. CaOx crystal deposition in the renal transplant may also be secondary to any of the causes associated with this phenotype in the native kidney. The pathophysiology underlying CaOx deposition is complex but this histological phenotype may indicate serious underlying pathology and should always warrant further investigation. Springer Berlin Heidelberg 2020-07-27 2020 /pmc/articles/PMC7496019/ /pubmed/32719990 http://dx.doi.org/10.1007/s00240-020-01202-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Invited Review
Geraghty, R.
Wood, K.
Sayer, J. A.
Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
title Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
title_full Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
title_fullStr Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
title_full_unstemmed Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
title_short Calcium oxalate crystal deposition in the kidney: identification, causes and consequences
title_sort calcium oxalate crystal deposition in the kidney: identification, causes and consequences
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496019/
https://www.ncbi.nlm.nih.gov/pubmed/32719990
http://dx.doi.org/10.1007/s00240-020-01202-w
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