Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid‐State NMR Spectroscopy

Positron emission tomography (PET) tracer molecules like thioflavin T specifically recognize amyloid deposition in brain tissue by selective binding to hydrophobic or aromatic surface grooves on the β‐sheet surface along the fibril axis. The molecular basis of this interaction is, however, not well...

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Detalles Bibliográficos
Autores principales: Niu, Zheng, Sarkar, Riddhiman, Aichler, Michaela, Wester, Hans‐Jürgen, Yousefi, Behrooz Hooshyar, Reif, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496087/
https://www.ncbi.nlm.nih.gov/pubmed/32291951
http://dx.doi.org/10.1002/cbic.202000143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496087/
https://www.ncbi.nlm.nih.gov/pubmed/32291951
http://dx.doi.org/10.1002/cbic.202000143

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